0000000000547548

AUTHOR

K. Pan

showing 3 related works from this author

TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)

2012

ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…

medicine.medical_specialtyGastrointestinal tumorsPerformance statusbusiness.industryHematologySevere hypoxiaNeutropeniamedicine.diseaseRashGastroenterologyDiscontinuationNon colorectalOncologyInternal medicineToxicitymedicinemedicine.symptombusinessAnnals of Oncology
researchProduct

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3a

2022

Abbott, R., et al. (LIGO and VIRGO Collaboration)

neutron star: binaryGravitational waves(678)ELECTROMAGNETIC COUNTERPARTSBinary numberAstrophysics01 natural sciencesLIGOHigh-Energy Phenomena and Fundamental PhysicsQCSUPERNOVAQBHigh Energy Astrophysical Phenomena (astro-ph.HE)Settore FIS/01education.field_of_study[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph]Black holesSettore FIS/0506 humanities and the artsGRBEnergy InjectionSearch for gravitational wave transients associated to GRBs - Fermi and Swift satellitesAFTERGLOWPhysical SciencesRELATIVISTIC JETSAstrophysics - High Energy Astrophysical PhenomenaSwiftGravitational waveBlack-Hole330Evolutiongr-qcGamma Ray Burst LIGO Virgo Gravitational WavesAstrophysics::High Energy Astrophysical PhenomenaGeneral Relativity and Quantum Cosmology (gr-qc)0603 philosophy ethics and religionGravitational-wave astronomyNeutron starsENERGY INJECTIONCORE-COLLAPSEeducationGamma-ray burstScience & TechnologyCore-CollapseVirgoRCUKAstronomy and AstrophysicstriggerLuminosity FunctionDewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie KartographieGamma Ray BurstSpace and Planetary ScienceBLACK-HOLEddc:520gravitational wave astronomyGravitational wave astronomyGamma-ray burst[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]LIGO(920)Fermi Gamma-ray Space TelescopeAstronomyAstrophysicsGeneral Relativity and Quantum Cosmologyneutron starsENERGYGravitational wave detectorsGamma-ray bursts(629)Neutron Stars Mergers Gravitational Waves010303 astronomy & astrophysicsgravitational waves; gamma ray bursts; LIGO; Virgo; Fermi; SwiftCompact binary stars(283)astro-ph.HEPhysicscompact binary starsgamma-ray burstsgamma-ray bursts ; gravitational waves; LIGO; Virgogravitational waves060302 philosophy[PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc]PRECURSOR ACTIVITYGravitational wave astronomy(675)Gamma-ray burstsGW_HIGHLIGHT[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]PopulationCompact binary starssatelliteFOS: Physical sciencesAstrophysics::Cosmology and Extragalactic AstrophysicsAstronomy & Astrophysicsgamma ray: burstMASS1STGLASTGamma-ray bursts; Gravitational wave astronomy; Gravitational waves; Gravitational wave detectors0103 physical sciencesSTFCFermigravitational waves; gamma-ray bursts; LIGO; Virgo; Fermi; SwiftGravitational wavegravitational radiationgamma ray burstsgamma-ray burts--black holesLIGOEVOLUTIONOBSERVING RUNNeutron stars(1108)Neutron starPhysics and Astronomy[SDU]Sciences of the Universe [physics]LUMINOSITY FUNCTIONBlack holes(162)INJECTIONEMISSION
researchProduct

Measurement of double-polarization asymmetries in the quasi-elastic Process

2018

We report on a precise measurement of double-polarization asymmetries in electron-induced breakup of He3 proceeding to pd and ppn final states, performed in quasi-elastic kinematics at Q2=0.25(GeV/c)2 for missing momenta up to 250MeV/c. These observables represent highly sensitive tools to investigate the electromagnetic and spin structure of He3 and the relative importance of two- and three-body effects involved in the breakup reaction dynamics. The measured asymmetries cannot be satisfactorily reproduced by state-of-the-art calculations of He3 unless their three-body segment is adjusted, indicating that the spin-dependent part of the nuclear interaction governing the three-body breakup pr…

PhysicsNuclear and High Energy Physics010308 nuclear & particles physicsNuclear TheoryObservableKinematicsSpin structurePolarization (waves)Breakup01 natural sciencesp-processNuclear interactionNuclear physicsReaction dynamics0103 physical sciencesNuclear Experiment010306 general physicsPhysics Letters
researchProduct