0000000000548245

AUTHOR

Carlos Belmonte

showing 2 related works from this author

Arginine-rich peptides are blockers of VR-1 channels with analgesic activity

2000

Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR channel activity may act as selective and potent analgesics. We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore. Dynorphins, natural arginine-rich peptides, also blocked VR-1 activity with micromolar affinity. Notably, synthetic and natural arginine-rich peptides attenuated the ocular irritation produced by topical capsaicin application onto the eye…

ArginineReceptors DrugBiophysicsTRPV Cation ChannelsPainDynorphinPharmacologyArginineEyeDynorphinsBiochemistryInhibitory Concentration 50MiceXenopus laevisDynorphinchemistry.chemical_compoundStructural BiologyNon-competitive antagonistGeneticsAnimalsChannel blockerAmino Acid SequenceBinding siteReceptorMolecular BiologyNon-competitive antagonistAnalgesicsChemistryElectric ConductivityNociceptorCell BiologyCapsaicinIonic poreOocytesNociceptorCapsaicinPeptidesFEBS Letters
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Building Bridges through Science

2017

WOS: 000415310800007 PubMed ID: 29144972 Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge'' initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities. Medical Research Council [MC_UP_1202/5]

Historyhistory 15th centuryhistory 21st centuryhistory medievalInternational CooperationNeurophysiologyEurope; history 15th century; history 21st century; history ancient; history medieval; humans; middle east; neurosciences; international cooperation; neuroscience (all)Bridge (interpersonal)History 21st CenturyAncient03 medical and health sciencesMiddle East0302 clinical medicinehistory ancientPolitical scienceHumansThrough ScienceHistory AncientHistory 15th CenturyEurope; History 15th Century; History 21st Century; History Ancient; History Medieval; Humans; Middle East; Neurosciences; International Cooperation; Neuroscience (all)Neuroscience (all)General NeuroscienceBuilding BridgesNeurosciences21st CenturyHistory Medieval030227 psychiatry3. Good healthEurope15th CenturyGeneral partnershipEngineering ethics030217 neurology & neurosurgeryMedieval
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