Author: P. Gruschwitz

0000000000548872

AUTHOR

P. Gruschwitz

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A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.

1981

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.

Inotropemedicine.medical_specialtyIBMXPhosphodiesterase InhibitorsStimulationCellular and Molecular Neurosciencechemistry.chemical_compoundCyclic gmpTheophyllineInternal medicine1-Methyl-3-isobutylxanthinePapaverinemedicineAnimalsTheophyllineMolecular BiologyPharmacologyPapaverineDose-Response Relationship DrugPhosphodiesteraseCell BiologyMyocardial ContractionAcetylcholineEndocrinologychemistryDepression ChemicalCatsMolecular MedicineAcetylcholinemedicine.drugExperientia

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