6533b824fe1ef96bd1280b31

RESEARCH PRODUCT

A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.

X. ZongP. GruschwitzH. Nawrath

subject

Inotropemedicine.medical_specialtyIBMXPhosphodiesterase InhibitorsStimulationCellular and Molecular Neurosciencechemistry.chemical_compoundCyclic gmpTheophyllineInternal medicine1-Methyl-3-isobutylxanthinePapaverinemedicineAnimalsTheophyllineMolecular BiologyPharmacologyPapaverineDose-Response Relationship DrugPhosphodiesteraseCell BiologyMyocardial ContractionAcetylcholineEndocrinologychemistryDepression ChemicalCatsMolecular MedicineAcetylcholinemedicine.drug

description

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.

yearjournalcountryeditionlanguage
1981-07-15Experientia
10.1007/bf01967963https://pubmed.ncbi.nlm.nih.gov/6168488