0000000000549090

AUTHOR

Alberto Fernández-medarde

showing 3 related works from this author

Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells

2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License .

MaleComputingMilieux_LEGALASPECTSOFCOMPUTINGTranscriptomeCytosolRas-GRF1Insulin-Secreting CellsGlucose homeostasisPromoter Regions GeneticOligonucleotide Array Sequence AnalysisMice KnockoutGeneticsCell biologySecurinERKPhenotypemedicine.anatomical_structureMitogen-Activated Protein KinasesBeta cellSignal transductionResearch ArticleSignal TransductionBiotechnologyCell signalingMedicina InvestigacióMedicinaPancreatic isletsBiologyGeneticsmedicineAnimalsCell LineagePttg1TranscriptomicsTranscription factorBinding Sitesras-GRF1Gene Expression ProfilingPancreatic isletsBeta cellsMolecular Sequence AnnotationGlucose Tolerance TestMice Inbred C57BLPàncrees MalaltiesGenetic LociData_GENERALTranscriptional factorsras ProteinsCalciumRasGrf1RasBMC Genomics
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Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice

2018

© 2018 The Authors.

0301 basic medicineMaleMemory Long-TermHippocampusSpatial learningBiologyHippocampusBarnes mazememory03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineDiscrimination PsychologicalMemoryAnimalsPttg1Maze LearningChromosome separationOriginal ResearchMice KnockoutPCALong-term memoryras-GRF1spatial learningBrainBarnes mazeMice Inbred C57BLSecurin030104 developmental biologySecurinCervell Localització de funcionsMemory consolidationFemaleSignal transductionBeta cellRasGrf1Neuroscience030217 neurology & neurosurgerySignal Transduction
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Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumpti…

2011

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene ( AUTS2 ) was associated with alcohol consumption at genome-wide significance ( P = 4 × 10 −8 to P = 4 × 10 −9 ). We found a genotype-specific expression of AUTS2 in 9…

Netherlands Twin Register (NTR)alcohol consumptionPopulationautismSingle-nucleotide polymorphismGenome-wide association studygenome-wide analysis; epidemiologic; transcriptional expression analysis; alcohol consumption; autismBiologyQuantitative trait locus03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingADDICTIVE BEHAVIORDEPENDENCEGenotype/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_medicineSNPeducationGenotyping030304 developmental biologyGenetics0303 health scienceseducation.field_of_studyMultidisciplinaryepidemiologicMENAlcohol Drinking/genetics; Alcohol Drinking/metabolism; Animals; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; European Continental Ancestry Group/genetics; Female; Gene Expression Regulation/genetics; Genome-Wide Association Study; Genotype; Humans; Male; Mice; Nuclear Proteins/biosynthesis; Nuclear Proteins/genetics; Polymorphism Single Nucleotide; Proteins/genetics; Proteins/metabolism; Quantitative Trait HeritableBiological Sciencesmedicine.diseaseGENOTYPES3. Good healthDROSOPHILA/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingAutismtranscriptional expression analysis030217 neurology & neurosurgerygenome-wide analysisProceedings of the National Academy of Sciences of the U.S.A.
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