0000000000549709

AUTHOR

Sylvia L. Asa

showing 3 related works from this author

Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants

2015

et al.

Maleendocrine system diseasesEndocrinology Diabetes and MetabolismClinical BiochemistryPapillaryAdult; Carcinoma; Carcinoma Papillary; Cohort Studies; Female; Follow-Up Studies; Gene Frequency; Humans; Male; Middle Aged; Neoplasm Metastasis; Prevalence; Prognosis; Radiotherapy; Retrospective Studies; Risk Assessment; Thyroid Cancer Papillary; Thyroid Neoplasms; Neoplasm Recurrence LocalThyroid CancerBiochemistryPapillary thyroid cancerCohort StudiesThyroid carcinoma Papillary Thyroid Carcinoma Variants Prognosis0302 clinical medicineEndocrinologyGene FrequencyInterquartile rangePrevalenceNeoplasm MetastasisMiddle AgedPrognosisDiabetes and MetabolismLocalThyroid Cancer Papillary030220 oncology & carcinogenesisFemaleCohort studyAdultmedicine.medical_specialtyBiochemistry; Clinical Biochemistry; Endocrinology; Biochemistry (medical); Endocrinology Diabetes and Metabolism030209 endocrinology & metabolismContext (language use)Risk AssessmentThyroid carcinoma03 medical and health sciencesInternal medicinemedicineCarcinomaHumansThyroid NeoplasmsRetrospective StudiesRadiotherapybusiness.industryBiochemistry (medical)CarcinomaCancerRetrospective cohort studyOriginal Articlesmedicine.diseaseCarcinoma PapillaryEndocrinologyNeoplasm RecurrenceNeoplasm Recurrence LocalbusinessFollow-Up Studies
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Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring

2022

Ki-67 assessment is a key step in the diagnosis of neuroendocrine neoplasms (NENs) from all anatomic locations. Several challenges exist related to quantifying the Ki-67 proliferation index due to lack of method standardization and inter-reader variability. The application of digital pathology coupled with machine learning has been shown to be highly accurate and reproducible for the evaluation of Ki-67 in NENs. We systematically reviewed all published studies on the subject of Ki-67 assessment in pancreatic NENs (PanNENs) employing digital image analysis (DIA). The most common advantages of DIA were improvement in the standardization and reliability of Ki-67 evaluation, as well as its spee…

Reproducibility of ResultsBreast NeoplasmsCarcinoid TumorPathology and Forensic MedicinePancreatic Neoplasmsneuroendocrine neoplasms pancreasNeuroendocrine TumorsKi-67 AntigenGastroenteropancreatic Neuroendocrine TumorBiomarkers TumorImage Processing Computer-AssistedHumansGastroenteropancreatic Neuroendocrine Tumor; Cancer; Carcinoid TumorFemaleCell ProliferationCancer
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Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and m…

2014

ObjectiveAlthough the succinate dehydrogenase (SDH)-related tumor spectrum has been recently expanded, there are only rare reports of non-pheochromocytoma/paraganglioma tumors in SDHx-mutated patients. Therefore, questions still remain unresolved concerning the aforementioned tumors with regard to their pathogenesis, clinicopathological phenotype, and even causal relatedness to SDHx mutations. Absence of SDHB expression in tumors derived from tissues susceptible to SDH deficiency is not fully elucidated.Design and methodsThree unrelated SDHD patients, two with pituitary adenoma (PA) and one with papillary thyroid carcinoma (PTC), and three SDHB patients affected by renal cell carcinomas (RC…

AdenomaAdultMalemedicine.medical_specialtyPathologySDHBEndocrinology Diabetes and MetabolismSDHALoss of HeterozygosityBiologyPheochromocytomaLoss of heterozygosityEndocrinologyParagangliomaInternal medicinemedicineHumansPituitary NeoplasmsThyroid NeoplasmsCarcinoma Renal CellGerm-Line MutationCarcinomaGeneral MedicineExonsMiddle Agedmedicine.diseaseNeuroblastic TumorCarcinoma Papillary3. Good healthNeoplasm ProteinsSuccinate DehydrogenaseEndocrinologyThyroid Cancer PapillaryMutationFemaleSDHDClear cellGene DeletionEuropean Journal of Endocrinology
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