0000000000550132

AUTHOR

Tatiana Kisseleva

showing 3 related works from this author

Evidence for a common progenitor of epithelial and mesenchymal components of the liver

2013

Tissues of the adult organism maintain the homeostasis and respond to injury by means of progenitor/stem cell compartments capable to give rise to appropriate progeny. In organs composed by histotypes of different embryological origins (e.g. The liver), the tissue turnover may in theory involve different stem/precursor cells able to respond coordinately to physiological or pathological stimuli. In the liver, a progenitor cell compartment, giving rise to hepatocytes and cholangiocytes, can be activated by chronic injury inhibiting hepatocyte proliferation. The precursor compartment guaranteeing turnover of hepatic stellate cells (HSCs) (perisinusoidal cells implicated with the origin of the …

Cellular differentiationLiver Stem CellDesminMice0302 clinical medicineMESH: AnimalsMESH: Nerve Tissue ProteinsHepatic stellate cellCells Cultured0303 health sciencesMesenchymal Stromal CellStem CellsCell DifferentiationCell biologyEndothelial stem cellMESH: DesminMESH: Models AnimalLiverMESH: Epithelial CellsDifferentiationModels Animal030211 gastroenterology & hepatologyStem cellMESH: Stem Cell Transplantationhepatic stellate cell; cell transplantation; liver stem cell; differentiationMESH: Cells CulturedMESH: Cell DifferentiationCell transplantation; Differentiation; Hepatic stellate cell; Liver stem cell; Animals; Cell Differentiation; Cell Line; Cell Lineage; Cell Proliferation; Cells Cultured; Desmin; Epithelial Cells; Glial Fibrillary Acidic Protein; In Vitro Techniques; Liver; Mesenchymal Stromal Cells; Mice; Mice Nude; Models Animal; Nerve Tissue Proteins; Stem Cell Transplantation; Stem Cells; Cell Biology; Molecular BiologyClinical uses of mesenchymal stem cellsMice NudeNerve Tissue ProteinsMESH: Stem Cells[SDV.BC]Life Sciences [q-bio]/Cellular BiologyBiologyIn Vitro TechniquesCell Line03 medical and health sciencesStem CellMESH: Cell ProliferationGlial Fibrillary Acidic ProteinMESH: Mice NudeAnimalsCell LineageProgenitor cellMESH: MiceMolecular Biology030304 developmental biologyCell ProliferationOriginal PaperEpithelial CellAnimalIn Vitro TechniqueMesenchymal stem cellEpithelial CellsMesenchymal Stem CellsCell BiologyMESH: Cell LineageMESH: Cell LineLiver stem cellNerve Tissue ProteinHepatic stellate cellMESH: Mesenchymal Stromal CellsCell transplantationMESH: LiverStem Cell Transplantation
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Hepatic progenitors for liver disease: current position

2010

Alice Conigliaro1, David A Brenner2, Tatiana Kisseleva21University “La Sapienza”, Dipartimento di Biotecnologie Cellulari ed Ematologia Policlinico Umberto I, V Clinica Medica, Rome, Italy; 2Department of Medicine, University of California, San Diego, La Jolla, CA, USAAbstract: Liver regeneration restores the original functionality of hepatocytes and cholangiocytes in response to injury. It is regulated on several levels, with different cellular populations contributing to this process, eg, hepatocytes, liver precursor cells, intrahepatic stem cells. In response to injury, mature hepatocytes have the capability to proliferate and give rise to new hepatocytes and cholangi…

Pathologymedicine.medical_specialtyoval cellsLiver cytologyMedicine (miscellaneous)cholangiocytes; hepatic progenitor; hepatocytes; intrahepatic stem cells; liver disease; liver precursor cells; oval cellsReviewBiologyhepatocytemedicinecholangiocytesProgenitor cellliver precursor cellQH573-671Mesenchymal stem cellintrahepatic stem cellCell Biologyhepatic progenitorliver precursor cellsintrahepatic stem cellsLiver regenerationCell biologyHaematopoiesisAmniotic epithelial cellsHepatic stellate cellhepatocytesStem cellCytologyliver diseasecholangiocyteStem Cells and Cloning: Advances and Applications
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Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.

2019

Background & Aims Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular inflammasome release in liver disease is unknown. Methods We used primary mouse and human hepatocytes, hepatocyte-specific leucine 351 to proline Nlrp3KICreA mice, and GsdmdKO mice to investigate pyroptotic cell death in hepatocytes and its impact on liver inflammation and damage. Extracellular NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasomes were isolated from mutant NLRP3-YFP HEK cells and internalisation was studied in LX2 and primary human hepatic stellate cells. We also examined a cohort of 154…

0301 basic medicineLiver CirrhosisInflammasomesInterleukin-1betaArticle03 medical and health sciencesLiver diseaseMice0302 clinical medicineMice Inbred NODNon-alcoholic Fatty Liver DiseaseNLR Family Pyrin Domain-Containing 3 ProteinmedicineHepatic Stellate CellsPyroptosisAnimalsHumansLiver injuryHepatologyChemistryFatty liverCaspase 1PyroptosisInflammasomemedicine.disease3. Good healthCell biology030104 developmental biologymedicine.anatomical_structureHepatocyteHepatic stellate cellHepatocytesProtein Translocation Systems030211 gastroenterology & hepatologySteatohepatitisReactive Oxygen Speciesmedicine.drugJournal of hepatology
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