0000000000550141

AUTHOR

K. Schrör

showing 4 related works from this author

ACTIONS OF PROSTAGLANDIN E2 ON MYOCARDIAL MECHANICS, CORONARY VASCULAR RESISTANCE AND OXYGEN CONSUMPTION IN THE GUINEA-PIG ISOLATED HEART PREPARATION

1975

Abstract 1 In isolated, electrically driven (3 Hz) hearts of guinea-pigs the action of prostaglandin E2 on left ventricular pressure (LVP), oxygen consumption (Qo2) and coronary vascular resistance (CVR) was studied by establishing cumulative concentration-response curves. The hearts were perfused at a constant flow (10 ml/min) with Tyrode solution (Ca++ 1.8 mM) at 32 degrees C. 2 Under control conditions prostaglandin E2 (2.86 X10(-11) -1.43 X 10(-7) M) decreased LVP, QO2 and CVR in a concentration-dependent manner by maximally 27, 18 and 38%, respectively (P less than 0.05). 3 After reserpine pretreatment there were lower initial values for all parameters measured. The effect of prostagla…

Malemedicine.medical_specialtyReserpineTime Factorsmedicine.medical_treatmentGuinea PigsBlood PressureIn Vitro TechniquesCoronary circulationOxygen ConsumptionHeart RateCoronary CirculationInternal medicineHeart ratemedicineAnimalsProstaglandin E2Pharmacologybusiness.industryProstaglandins EHeartReserpineMyocardial Contractionmedicine.anatomical_structureEndocrinologyBlood pressureVascular resistanceVentricular pressureFemaleVascular ResistancebusinessResearch Articlemedicine.drugProstaglandin EBritish Journal of Pharmacology
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The specificity of prostaglandin E2 (PGE2) in reducing coronary vascular resistance: A comparison with adenosine.

1978

Experiments were performed on the isolated, electrically driven guinea-pig heart, perfused at constant rate. All animals were pretreated with reserpine. Myocardial contractile force (MCF), coronary perfusion pressure (CPP) and myocardial oxygen consumption (QO2) were monitored continuously. Both adenosine (ADO) and PGE2 produced a concentration-dependent decrease in the CPP. The ED50 (50% of maximum response) was 2.1 +/- 0.6 X 10(-9)M for PGE2 but 40 +/- 7 X 10(-9)M for ADO (P less than 0.01) at 1.8 mM Ca(e). This coronary vasodilation was independent of the external Ca-concentration, which was varied between 0.55-9.0 mM. PGE2 had no effect on MCF or QO2 and the effect of ADO was only sligh…

Malemedicine.medical_specialtyAdenosinePhysiologyGuinea Pigschemistry.chemical_elementProstaglandinBlood PressureOxygenchemistry.chemical_compoundOxygen ConsumptionPhysiology (medical)Internal medicinemedicineAnimalsProstaglandin E2Prostaglandins EReserpineAdenosineCoronary VesselsPerfusionConstant ratemedicine.anatomical_structurechemistryCardiologyCoronary perfusion pressureVascular resistanceFemaleVascular ResistanceCardiology and Cardiovascular Medicinemedicine.drugBasic research in cardiology
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Prostaglandin A2 (PGA2) increases the coronary vascular resistance in the guinea-pig isolated heart preparation.

1977

Prostaglandin A2 (PGA2) in concentrations of 1.5·10−8 to 3·10−6 M was found to produce concentration-dependent increase in the coronary vascular resistance of the guinea-pig isolated heart without alterations in myocardial contractile force and oxygen consumption.

Isolated Heart PreparationMalemedicine.medical_specialtyGuinea PigsProstaglandinPharmacologyGuinea pigCellular and Molecular Neurosciencechemistry.chemical_compoundInternal medicinemedicineAnimalsMolecular BiologyPharmacologyProstaglandins ADose-Response Relationship Drugbusiness.industryCell BiologyIsolated heartCoronary VesselsMyocardial Contractionmedicine.anatomical_structurechemistryVascular resistanceCardiologyMolecular MedicineFemaleVascular ResistancebusinessExperientia
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INTERACTIONS OF ISOPRENALINE AND PROSTAGLANDIN E2 WITH RESPECT TO MYOCARDIAL CONTRACTILE FORCE, CORONARY VASCULAR RESISTANCE AND MYOCARDIAL OXYGEN CO…

1976

Left ventricular pressure (LVP), left ventricular pressure derivative (LV dp/dtmax), coronary vascular resistance (CVR) and myocardial oxygen consumption (Qo2) were measured simultaneously in isolated, electrically driven hearts of guinea-pigs at constant perfusion rate. 2 LVP, LV dp/dtmax, CVR and Qo2 were greatly decreased by either the addition of prostaglandin E2 (50 ng/ml) to the perfusion fluid or pretreatment of the animals with reserpine. 3 Isoprenaline (0.5 nM to 100 nM) induced increases in LVP, LV dp/dtmax and Qo2. In the presence of prostaglandin E2, there was a parallel shift of the isoprenaline concentration-response curve for LVP and LV dp/dtmax. This effect was not seen, aft…

Malemedicine.medical_specialtyReserpinemedicine.medical_treatmentGuinea PigsIndomethacinProstaglandinBlood PressureNorepinephrinechemistry.chemical_compoundOxygen ConsumptionInternal medicineIsoprenalinemedicineAnimalsDrug InteractionsProstaglandin E2PharmacologyDose-Response Relationship Drugbusiness.industryMyocardiumProstaglandins EIsoproterenolReserpineCoronary VesselsMyocardial ContractionBlood pressuremedicine.anatomical_structurechemistryCardiologyVentricular pressureVascular resistanceFemaleVascular ResistancebusinessResearch Articlemedicine.drugProstaglandin EBritish Journal of Pharmacology
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