In vivo high-throughput identification of olfactory receptor repertoire coding for a blending mixture

2019

International audience

High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice

2016

AbstractType 2 Diabetes (T2D), a major public health issue reaching worldwide epidemic, has been correlated with lower olfactory abilities in humans. As olfaction represents a major component of feeding behavior, its alteration may have drastic consequences on feeding behaviors that may in turn aggravates T2D. In order to decipher the impact of T2D on the olfactory epithelium, we fed mice with a high fructose diet (HFruD) inducing early diabetic state in 4 to 8 weeks. After only 4 weeks of this diet, mice exhibited a dramatic decrease in olfactory behavioral capacities. Consistently, this decline in olfactory behavior was correlated to decreased electrophysiological responses of olfactory n…

Negative impact of high fructose diet on olfactory habilities

2014

National audience

Impact of diets unbalanced in n-3 polyunsaturated fatty acids on the mouse olfactory function

2021

Negative impact of high fructose diet on olfactory abilities

2014

Negative impact of high fructose diet on olfactory performances: behavioral and functional analysis

2014

Negative impact of high fructose diet on olfactory performances: behavioral and functional analysis. 9. Forum of Neuroscience FENS

Early impact of a diabetes inducing high-fructose diet on olfaction in mice

2015

The influence of nutritional status on olfactory processes has been thoroughly investigated over the last few years. It is now well-established that both nutritional status and hormones implicated in food metabolism can effectively modulate the olfactory system from the single neuron to the behavior. Therefore, it seems likely that metabolic disorders such as type 2 diabetes (T2D) can induce olfactory dysfunctions. Indeed T2D patients display poor olfactory performances although the direct effects of diabetes on olfaction were not yet demonstrated. Here, we investigated the modulation of olfaction in young adult (5 weeks old) C57Bl/6 male mice caused by a high-fructose diet (HFruD), known t…

Impact of a high fat high sucrose maternal diet on the progeny's olfactory system

2018

International audience

Multidisciplinary approach to explore interactions in odor mixture perception

2023

Odors and aromas perceived in food and in the environment result from the processing of complex chemical mixtures of volatile compounds that should be efficiently processed by the olfactory system. It is known for decades that this processing generates perceptual interactions, such as masking, synergy, or perceptual blending, which contribute to elaborating a synthetic brain representation of the chemical information. Nevertheless, the perceptual processes underlying these interactions are still poorly known. In this project, we set out a multidisciplinary approach to identify the characteristics of odorants and olfactory receptors (ORs) that could support perceptual interactions. We hypoth…

Impact of a maternal high fat high sucrose diet on progeny's olfactory system

2018

International audience

impact of dietary intake of n-3 polyunsaturated fatty acids on the physiology of the peripheral olfactory system in young mice

2021

Abstract : Olfaction plays a major role in the detection of volatile chemical signals present in the environment and triggers behaviors such as food intake, social interactions or danger avoidance. Recent studies suggested that nutritional and metabolic status of individuals may influence their olfactory capacities. Olfactory disorders have been observed in people with pathologies such as obesity and diabetes as well as in rodents exposed to obesogenic or diabetogenic diets. The physiological mechanisms underlying these dysfunctions are not known. One hypothesis is that a nutritional imbalance in lipids might alter the functioning of the peripheral olfactory system. In this context, the obj…