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RESEARCH PRODUCT
High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice
Denise GrebertElise Léger-charnayElise Léger-charnayElise Léger-charnayDavid JarriaultDavid JarriaultDavid JarriaultAdrien MolinasAdrien MolinasAdrien MolinasXavier GrosmaitreXavier GrosmaitreXavier GrosmaitreSébastien RivièreSébastien RivièreSébastien RivièreNicolas MeunierNicolas MeunierVanessa SoubeyreVanessa SoubeyreVanessa SoubeyreLucie DesmoulinsLucie DesmoulinsLucie Desmoulinssubject
0301 basic medicineOlfactory systemmedicine.medical_specialtyolfaction;fructose;diabete;physiology;behavior;mouseinjuryPopulationType 2 diabetesOlfactionBiologysystemleptinArticleinsulin-resistance03 medical and health sciencescardiac-hypertrophyneuropeptide-y0302 clinical medicineInsulin resistance[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyInternal medicineDiabetes mellitusmedicineFood and Nutritioneducationmarker proteineducation.field_of_studyMultidisciplinaryLeptinNeurosciencesapoptosismedicine.disease3. Good health030104 developmental biologyEndocrinologymedicine.anatomical_structuresensory neuronsNeurons and CognitionAlimentation et NutritionOlfactory epithelium030217 neurology & neurosurgery[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologymellitusdescription
AbstractType 2 Diabetes (T2D), a major public health issue reaching worldwide epidemic, has been correlated with lower olfactory abilities in humans. As olfaction represents a major component of feeding behavior, its alteration may have drastic consequences on feeding behaviors that may in turn aggravates T2D. In order to decipher the impact of T2D on the olfactory epithelium, we fed mice with a high fructose diet (HFruD) inducing early diabetic state in 4 to 8 weeks. After only 4 weeks of this diet, mice exhibited a dramatic decrease in olfactory behavioral capacities. Consistently, this decline in olfactory behavior was correlated to decreased electrophysiological responses of olfactory neurons recorded as a population and individually. Our results demonstrate that, in rodents, olfaction is modified by HFruD-induced diabetes. Functional, anatomical and behavioral changes occurred in the olfactory system at a very early stage of the disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-23 |