Negative impact of high fructose diet on olfactory habilities

2014

National audience

Negative impact of high fructose diet on olfactory abilities

2014

Plasticity in the olfactory system: modulation by the odorant environment and diet

2015

As the primary neuronal element in the olfactory system, olfactory sensory neurons (OSNs) are responsible for detecting odor molecules, transforming chemical information to electrical signals and sending these signals to the brain. Being exposed to the environment, their lifetime is limited. The olfactory epithelium has the remarkable ability to regenerate sensory neurons throughout life. There is little data showing the effects of the environment, such as odorant exposure, on the properties of OSNs. Similarly, knowledge on the modulation by the physiological state of the animal (i.e. nutritional status) is limited. The long-term goal of our group is to investigate how the OSNs function dur…

Negative impact of high fructose diet on olfactory performances: behavioral and functional analysis

2014

Negative impact of high fructose diet on olfactory performances: behavioral and functional analysis. 9. Forum of Neuroscience FENS

Early impact of a diabetes inducing high-fructose diet on olfaction in mice

2015

The influence of nutritional status on olfactory processes has been thoroughly investigated over the last few years. It is now well-established that both nutritional status and hormones implicated in food metabolism can effectively modulate the olfactory system from the single neuron to the behavior. Therefore, it seems likely that metabolic disorders such as type 2 diabetes (T2D) can induce olfactory dysfunctions. Indeed T2D patients display poor olfactory performances although the direct effects of diabetes on olfaction were not yet demonstrated. Here, we investigated the modulation of olfaction in young adult (5 weeks old) C57Bl/6 male mice caused by a high-fructose diet (HFruD), known t…

High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice

2016

AbstractType 2 Diabetes (T2D), a major public health issue reaching worldwide epidemic, has been correlated with lower olfactory abilities in humans. As olfaction represents a major component of feeding behavior, its alteration may have drastic consequences on feeding behaviors that may in turn aggravates T2D. In order to decipher the impact of T2D on the olfactory epithelium, we fed mice with a high fructose diet (HFruD) inducing early diabetic state in 4 to 8 weeks. After only 4 weeks of this diet, mice exhibited a dramatic decrease in olfactory behavioral capacities. Consistently, this decline in olfactory behavior was correlated to decreased electrophysiological responses of olfactory n…