0000000000557547
AUTHOR
Luca Massaccesi
showing 2 related works from this author
Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity
2019
Abstract Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for indoor and outdoor pest control. The main route of human exposure is through fruit, vegetable and milk intake. Low dosage exposure to permethrin during neonatal brain development (from postnatal day 6 to postnatal day 21) leads to dopamine decrease in rat striatum nucleus, oxidative stress and behavioural changes linked to the development of Parkinson's like neurodegeneration later in life. The aim of this study was to evaluate the expression of genes involved in the dopaminergic pathway and epigenetic regulatory mechanisms in adolescent rats treated with permethrin during neonatal brain developmen…
Biomarkers of Oxidative Stress in Acute and Chronic Diseases
2022
Molecular biomarkers consent to apply individual decisions in the complex management of both acute or chronic diseases, and their identification constitutes a fundamental phase for achieving the important object to develop personalized therapies [...]