0000000000557611

AUTHOR

Zdenko Herceg

showing 2 related works from this author

Molecular landscape of esophageal cancer: implications for early detection and personalized therapy

2018

Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical distribution, possibly due to differences in exposure to risk factors and lifestyles. ESCC and EAC are distinct diseases in terms of cell of origin, epidemiology, and molecular architecture of tumor cells. Past efforts aimed at translating potential molecular candidates into clinical practice proved to be challenging, underscoring the need for identifying novel candidates for …

0301 basic medicineOncologymedicine.medical_specialtyEsophageal Neoplasmsmedicine.medical_treatmentEarly detectionGenomicsDiseaseAdenocarcinomaGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineHistory and Philosophy of ScienceInternal medicineEpidemiologyHumansMedicineEarly Detection of CancerEpigenomicsbusiness.industryGeneral NeuroscienceEpigenomeImmunotherapyEsophageal cancermedicine.disease030104 developmental biology030220 oncology & carcinogenesisMutationEsophageal Squamous Cell CarcinomabusinessAnnals of the New York Academy of Sciences
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DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma

2019

A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or innate immunity plays a role in the obesity-asthma link. DNA methylome was measured in blood samples of 61 non-atopic participants with asthma and 146 non-atopic participants without asthma (non-smokers for at least 10 years) taking part in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) study. Modification by DNA methylation of the association of BMI or BMI change over 10 years with adult-onset asthma was examined at each CpG sit…

MaleobesityNon-atopic asthmaHealth Toxicology and Mutagenesislcsh:MedicineToxicologyBody Mass IndexCohort StudiesMice0302 clinical medicineMedicineinnate immunitynon-atopic asthmaInnate immunity0303 health sciencesDNA methylationNF-kappa Bepigenome-wide association study3. Good healthCpG siteDNA methylationFemaleEpigeneticsmedicine.symptomGlucocorticoidmedicine.drugAdultMAP Kinase Signaling SystemInflammationArticle03 medical and health sciencesEpigenome-wide association studyMD MultidisciplinaryAnimalsHumansObesityEpigeneticsadult-onset asthmaPI3K/AKT/mTOR pathway030304 developmental biologyAsthmaInflammationepigeneticsbusiness.industrylcsh:RPublic Health Environmental and Occupational Healthmedicine.diseaseObesityAsthmarespiratory tract diseasesPPAR gamma030228 respiratory systeminflammationImmunologybusinessAdult-onset asthmaInternational Journal of Environmental Research and Public Health
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