DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma

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RESEARCH PRODUCT

DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma

Gianfranco Lovison Medea Imboden Medea Imboden Anne-elie Carsin Christian Schindler Christian Schindler Paolo Vineis Andre F.s. Amaral Roel Vermeulen Alexei Novoloaca Akram Ghantous Ayoung Jeong Ayoung Jeong Cyrille Cuenin Deborah Jarvis Florian Kronenberg Manolis Kogevinas Zdenko Herceg Nicole Probst-hensch Nicole Probst-hensch

subject

Male obesity Non-atopic asthma Health Toxicology and Mutagenesis lcsh:Medicine Toxicology Body Mass Index Cohort Studies Mice 0302 clinical medicine Medicine innate immunity non-atopic asthma Innate immunity 0303 health sciences DNA methylation NF-kappa B epigenome-wide association study 3. Good health CpG site DNA methylation Female Epigenetics medicine.symptom Glucocorticoid medicine.drug Adult MAP Kinase Signaling System Inflammation Article 03 medical and health sciences Epigenome-wide association study MD Multidisciplinary Animals Humans Obesity Epigenetics adult-onset asthma PI3K/AKT/mTOR pathway 030304 developmental biology Asthma Inflammation epigenetics business.industry lcsh:R Public Health Environmental and Occupational Health medicine.disease Obesity Asthma respiratory tract diseases PPAR gamma 030228 respiratory system inflammation Immunology business Adult-onset asthma

description

A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or innate immunity plays a role in the obesity-asthma link. DNA methylome was measured in blood samples of 61 non-atopic participants with asthma and 146 non-atopic participants without asthma (non-smokers for at least 10 years) taking part in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) study. Modification by DNA methylation of the association of BMI or BMI change over 10 years with adult-onset asthma was examined at each CpG site and differentially methylated region. Pathway enrichment tests were conducted for genes in a priori curated inflammatory pathways and the NLRP3-IL1B-IL17 axis. The latter was chosen on the basis of previous work in mice. Inflammatory pathways including glucocorticoid/PPAR signaling (p = 0.0023), MAPK signaling (p = 0.013), NF-&kappa

year	journal	country	edition	language
2019-02-01	International Journal of Environmental Research and Public Health

10.3390/ijerph16040600 http://dx.doi.org/10.3390/ijerph16040600