0000000000559933
AUTHOR
Mohamed Hilmy Elnagdi
Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines
Reaction of enaminones 1a–d with 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2) in the presence of AcOH/NH4OAc afforded 7-amino-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbonitrile derivatives 9a–d. On the other hand, 2-aminopyrano[4,3,2-de] [1,6]naphthyridine-3-carbonitriles 20a–c,e were the only obtained products from the reactions of 1a–d with 2 in the presence of AcOH/NaOAc, while 1d afforded [3,5-bis-(4-chloro-benzoyl)-phenyl]-(4-chloro-phenyl)-methanone 21 under the same condition. The reaction of 2 with diethyl acetylenedicarboxylate in the presence of AcOH/NH4OAc afforded (4-cyano-5-dicyanomethylene-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-acetic acid eth…
Unambiguous structure elucidation of heterocyclic products from condensation-cyclisation reactions of enaminones by 2D INADEQUATE and 15 N NMR
The reaction of enaminones with 3-amino-2-cyanopent-2-enedinitrile can lead to an array of 12 possible products, depending on the reaction pathway and tautomerization. The use of 2D INADEQUATE and 15N NMR for the unambiguous structure elucidation of the reaction products is discussed in this manuscript. Copyright © 2012 John Wiley & Sons, Ltd.
CCDC 861196: Experimental Crystal Structure Determination
Related Article: Moustafa Sherief Moustafa, Saleh Mohammed Al-Mousawi, Noha Mohamed Hilmy, Yehia A. Ibrahim , Johannes C. Liermann, Herbert Meier, Mohamed Hilmy Elnagdi|2013|Molecules|18|276|doi:10.3390/molecules18010276
CCDC 838314: Experimental Crystal Structure Determination
Related Article: Moustafa Sherief Moustafa, Saleh Mohammed Al-Mousawi, Noha Mohamed Hilmy, Yehia A. Ibrahim , Johannes C. Liermann, Herbert Meier, Mohamed Hilmy Elnagdi|2013|Molecules|18|276|doi:10.3390/molecules18010276