0000000000563398
AUTHOR
S. Giordano
Acute pancreatitis in children and rotavirus infection. Description of a case and minireview
In this article, we describe a case of acute pancreatitis occurred on a 2-year-old boy following rotavirus gastroenteritis. Its characteristics are analyzed and contextualized among those of other 4 cases of pancreatitis associated with rotavirus infection found through a systematic review of the international literature. None of the five children underwent surgery or was referred to an intensive care unit and all the 5 children cured with normalization of pancreatic enzyme within 5-10 days. The pathogenesis of this rare complication remains to be cleared, and its actual incidence may be higher than that reported. Although acute pancreatitis associated with rotavirus gastroenteritis seems t…
Zygomycosis in Italy: A survey of FIMUA-ECMM (Federazione Italiana di Micopatologia Umana ed Animale and European Confederation of Medical Mycology)
Abstract The aims of the study were to analyze the clinical and epidemiological characteristics and treatments for patients who developed zygomycosis enrolled in Italy during the European Confederation of Medical Mycology of medical mycology survey. This prospective multicenter study was performed between 2004 and 2007 at 49 italian Departments. 60 cases of zygomycosis were enrolled: the median age was 59.5 years (range 1-87), with a prevalence of males (70%). The majority of cases were immunocompromised patients (42 cases, 70%), mainly hematological malignancies (37). Among non-immunocompromised (18 cases, 30%), the main category was represented by patients with penetrating trauma (7/18, 3…
Aspergillosi polmonare in soggetto con lupus eritematoso sistemico e sindrome da attivazione macrofagica
Le infezioni rappresentano una delle principali cause di morbilità e mortalità nei pazienti affetti da lupus eritematoso sistemico (LES). I fattori che determinano l’aumentata suscettibilità alle infezioni dipendono sia dalla patologia sia dai farmaci assunti. MR, 16 aa, affetta da LES, esordito 2 anni prima, in trattamento con idrossiclorochina, si ricovera per febbre elevata poco responsiva ad antipiretici. Due settimane prima riferiva comparsa di pseudotinea amantiacea al cuoio capelluto e otite da Pseudomonas aeruginosa per cui era in terapia con ciprofloxacina. Dopo 24 ore di ricovero, la ragazza sviluppa una sindrome da attivazione macrofagica (MAS) associata ad insufficienza renale a…
The first coronal mass ejection observed in both visible-light and UV HI Ly-α channels of the Metis coronagraph on board Solar Orbiter
Context.The Metis coronagraph on board Solar Orbiter offers a new view of coronal mass ejections (CMEs), observing them for the first time with simultaneous images acquired with a broad-band filter in the visible-light interval and with a narrow-band filter around the H ILy-αline at 121.567 nm, the so-called Metis UV channel.Aims.We show the first Metis observations of a CME, obtained on 16 and 17 January 2021. The event was also observed by the EUI/FSI imager on board Solar Orbiter, as well as by other space-based coronagraphs, such as STEREO-A/COR2 and SOHO/LASCO/C2, whose images are combined here with Metis data.Methods.Different images are analysed here to reconstruct the 3D orientation…
The return of anthrax. From bioterrorism to the zoonotic cluster of Sciacca district [Il ritorno del carbonchio. Dal bioterrorismo al focolaio zoonotico del distretto di Sciacca]
Anthrax is a disease caused by Bacillus anthracis which affects herbivorous animals. Humans acquire the disease incidentally by exposure to infected animals, animal products or spores on soil. The infection is still endemic in many regions in developing countries. In Italy animal clusters are very rare and human cases are exceptional. Bacillus anthrax is also a potential source for acts of bioterrorism. In the natural human infection, cutaneous anthrax is the most widespread, while the other two, pulmonary and gastrointestinal anthrax, are very rare forms. We describe the first case of human anthrax occurring in western Sicily in the last twenty years. The cutaneous lesion healed without si…
Pulmonary hydatid disease in childhood: a case report [Idatidosi polmonare in età infantile: Descrizione di un caso clinico]
Echinococcosis/hydatidosis is a parasitic zoonosis caused in humans by the larval stage of the Echinococcus granulosus cestode. Although notification of infestation is required, there are no reliable data on the prevalence of this parasitosis among humans in Italy. This zoonosis was first reported in ancient times (Hippocrates, fourth century BC) and since then many cases of echinococcosis/hydatidosis have been described. Currently, it is considered one of the main parasitoses affecting animals bred for income and one of the most important parasitic zoonoses. We present the clinical case of a three-year-old child, living in Palermo with a dog in his house, who came to our observation for dy…
TRE CASI DI MIOCARDITE ACUTA DA PARVOVIRUS B19
L’infezione da Parvovirus B19, responsabile del “megaloeritema infettivo”, può determinare conseguenze cliniche gravi, tra le quali: la miocardite acuta, la crisi aplastica del midollo osseo e l’artrite. Esponiamo tre casi clinici di miocardite acuta secondaria a infezione da Parvovirus B19 che hanno avuto decorso sfavorevole: S, femmina di 18 mesi, M, femmina di 3 anni, A, maschio di 2 anni. Le bambine riferivano anamnesi negativa, invece A era affetto da metilmalonico aciduria. S giungeva in PS dopo tre giorni di febbre: soporosa, pallida, dispnoica e tachicardica con soffio sistolico, crepitii alle basi polmonari ed epatomegalia. M riferiva astenia e iporessia da un mese e, all’ingresso …
Coronary involvement in Mediterranean spotted fever
Mediterranean spotted fever (MSF) is a tick-borne acute febrile disease caused by Rickettsia conorii and characterized by fever, a maculo-papular rash and a black eschar at the site of the tick bite. We describe the case of a 3-year-old boy with MSF who developed a transient right coronary artery ectasia. The patient was brought to the hospital after four days of fever and mild myalgia of the legs. The suspicion of MSF arose due to the presence of a maculo-papular skin rash and treatment with oral clarithromycin was started. After four days fever persisted and the differential diagnosis of Kawasaki syndrome was considered. Echocardiography showed a dilated right coronary artery with hyperre…
COVID-19 and relapsing Kawasaki disease: a case report during the pandemia
Introduction: The pandemia of COVID-19 remains a global health alarm with high incidence of lethality, especially in older age groups who suffer from underlying medical conditions. However, children are less likely to manifest severe conditions. Objectives: COVID-19 was correlated to a higher incidence and a suspected increased risk of Kawasaki Disease (KD) in children.
COVID-19 temporally related multisystem inflammatory syndrome (MIS-C): an early window of opportunity is a good treatment strategy? The experience of the paediatric covid center in Palermo
Introduction: Multi-system inflammatory syndrome in children (MISC) shows a presentation mimicking Kawasaki Disease (KD), Toxic Shock Syndrome (TSS), Macrophage Activation Syndrome (MAS). Furthermore, many children show respiratory or abdominal symptoms. Objectives: Intravenous immunoglobulin (IVIG) is recommended as first line treatment as in KD, followed by aspirin, steroids and, in IVIGresistant patients, IL-1 or IL-6 blocking agents. Methods: We describe a cohort of 16 Sicilian children (6M;10F; age:1.4-14 years), with MIS-C, with clinical features compatible with classical or incomplete KD, in some cases with MAS and/or TSS. Demographic, clinical, laboratory, echocardiographic and imag…
Spider bite mimicking pyoderma gangrenosum in sJIA: a case report
Introduction: Several paediatric patients manifest conditions commonly misdiagnosed as spider bites, which however, can include other arthropods bites; bacterial, viral, and mycotic infections; vasculitis; dermatological diseases; miscellaneous conditions as drug reactions, chemical injuries. Objectives: In Italy, spiders which are likely to be associated with severe toxin mediated tissue damage are uncommon, especially in urban zones. However, a minor trauma may be a precipitating factor for pyoderma gangrenosum particularly over the legs, in association with inflammatory bowel disease, haematologic diseases and Juvenile Idiopathic Arthritis (JIA).
[Anti-Pseudomonas aeruginosa antibodies and lung disease in cystic fibrosis]
The aim of our study was to diagnose and to control three aspects of the evolution of lung disease in CF: the absence of infection, the intermittent colonization and chronic infection by Pseudomonas aeruginosa. Therefore a study of anti-pseudomonas antibodies (Ab) (anti-protease, anti-elastin and antihexo-toxin A) for diagnosis and follow-up of CF patients was considered. Moreover, we related the presence of Ab to the sputum culture, to FEV1, to patient age and to genotype. Tbe Ab were dosed in 121 patients by quantitative ELISA method. Values < 1: 500 were considered negative, values> 1: 500 and < 1:1250 borderline, and > 1:1250 positive. 16.5% of patients did not have Ab, 17% …
MALATTIA DI KAWASAKI E MAS INDOTTA DA INFEZIONE DA EBV IN PAZIENTE CON LINFOISTIOCITOSI EMOFAGOCITICA DI TIPO 2
L’HLH, rara patologia da alterata risposta infiammatoria sistemica, presenta elevata mortalità, se non diagnosticata e trattata tempestivamente. Il quadro clinico è caratterizzato da febbre elevata persistente, epatosplenomegalia, citopenia di almeno due linee cellulari, linfoadenopatia generalizzata, rash, iperferritinemia, ipertrigliceridemia, ipofibrinogenemia, ipertransaminasemia e alterazioni della coagulazione. La HLH è divisa in primaria o familiare (autosomica recessiva) e secondaria (S. Autoinfiammatorie, infezioni, trapianti, ecc). La terapia si basa su chemioterapia (protocollo HLH94 e HLH2004) e, per le HLH familiari, e trapianto di midollo osseo. Fra le forme familiari, il tipo…