0000000000564189

AUTHOR

Wolfram Karges

showing 2 related works from this author

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

2006

Recently, we have identified proinsulin (P-Ins) 73-90 as an immunodominant T cell epitope of HLA-DRB1*0401 (DR4) subjects with β-islet cell autoimmunity and of HLA-DR4/CD4 double-transgenic mice immunized with human P-Ins. We have compared the fine specificities of one human CD4 T cell clone and two mouse T cell hybridoma clones recognizing this epitope, and, although these three clones all recognized the same core region (LALEGSLQK), there were major differences in how they interacted with the peptide (p)/HLA complex, reflecting the fact that human P-Ins is a foreign antigen in the mouse and an autoantigen in the type 1 diabetes patient. The human T cell clone was forkhead transcription f…

Regulatory T cellT cellT-LymphocytesMolecular Sequence DataClone (cell biology)Mice TransgenicHuman leukocyte antigenBiologyEpitopeEpitopesMiceAntigenT-Lymphocyte SubsetsmedicineCytotoxic T cellAnimalsHumansAmino Acid SequenceAmino AcidsMultidisciplinaryFOXP3Forkhead Transcription FactorsHLA-DR AntigensBiological SciencesMolecular biologyPeptide Fragmentsmedicine.anatomical_structurePhenotypeHLA-DRB1 ChainsProinsulinProceedings of the National Academy of Sciences of the United States of America
researchProduct

Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparison

2015

AimsImproving glycaemic control in people with Type1 diabetes is known to reduce complications. Our aim was to compare glycaemic control among people with Type1 diabetes using data gathered in regional or national registries. MethodsData were obtained for children and/or adults with Type1 diabetes from the following countries (or regions): Western Australia, Austria, Denmark, England, Champagne-Ardenne (France), Germany, Epirus, Thessaly and Thessaloniki (Greece), Galway (Ireland), several Italian regions, Latvia, Rotterdam (The Netherlands), Otago (New Zealand), Norway, Northern Ireland, Scotland, Sweden, Volyn (Ukraine), USA and Wales) from population or clinic-based registries. The sampl…

MaleDenmarkEndocrinology Diabetes and Metabolismmetabolic-controlregistryEndocrinologyGermanyInsulinMedicineadolescentsRegistriesYoung adultNetherlandseducation.field_of_studyGreeceNorway18 countriesClinical PracticeEnglandItalyAustriaPractice Guidelines as TopicFemaleFranceGuideline AdherenceUkraineAdultcomplicationsAdolescentPopulationNorthern IrelandNorthern irelandAge and sexYoung AdultInsulin Infusion SystemschildrenDiabetes mellitusInternal MedicineHumansHypoglycemic AgentscareeducationchildhoodGlycated HemoglobinSwedenType 1 diabetesWalesbusiness.industryWestern Australiamedicine.diseaseLatviaiddmUnited StatesDiabetes Mellitus Type 1ScotlandSample size determinationOptometrybusinessIrelandNew ZealandDemographyDiabetic Medicine
researchProduct