0000000000577915
AUTHOR
M. González Pérez
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Reparación de las fracturas de huesos largos en traumatismos craneoencefálicos: estudio experimental en la rata
Los pacientes con traumatismo craneoencefálico presentan una respuesta osteogénica alterada. Para estudiar si existe o no un callo de fractura más voluminoso o más prematuro en las fracturas de hueso largo se ha buscado un modelo experimental en rata Wistar con y sin lesión encefálica. El estudio no demuestra diferencias significativas. Se discute la importancia de factores terapéuticos más que el hecho del traumatismo creaneoencefálico. Osteogenic response deviates significantly in patients with traumatic brain injury. In this study, we analyze if there is an increased volume or earlier callus formation in long bones fractures in Wistar rats with and without brain injury. The results show …