0000000000585429
AUTHOR
David Andreu
showing 3 related works from this author
Estimation of Electrical Pathways Finding Minimal Cost Paths from Electro-Anatomical Mapping of the Left Ventricle
2014
The electrical activation of the heart is a complex physiological process that is essential for the understanding of several cardiac dysfunctions, such as ventricular tachycardia VT. Nowadays, electro-anatomical mappings of patient-specific activation times on the left ventricle surface can be estimated, providing crucial information to the clinicians for guiding cardiac treatment. However, some electrical pathways of particular interest such as Purkinje or still viable conduction channels are difficult to interpret in these maps. We present here a novel method to find some of these electrical pathways using minimal cost paths computations on surface maps. Experiments to validate the propos…
Quasi-Conformal Technique for Integrating and Validating Myocardial Tissue Characterization in MRI with Ex-Vivo Human Histological Data
2017
Ventricular tachycardia caused by a circuit of re-entry is one of the most critical arrhythmias. It is usually related with heterogeneous scar regions where slow velocity of conduction tissue is mixed with non-conductive tissue, creating pathways (CC) responsible for the tachycardia. Pre-operative DE-MRI can provide information on myocardial tissue viability and then improve therapy planning. However, the current DE-MRI resolution is not sufficient for identifying small CCs and therefore they have to be identified during the intervention, which requires considerable operator experience. In this work, we studied the relationship of histological data (with 10 \(\mu \)m resolution), with in-vi…
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
2019
AbstractAs the catalogue of oncogenic driver mutations is expanding, it is becoming clear that alterations in a given gene should not be lumped into one single class, since they might have different functions. The transcription factorGATA3is a paradigm of this. Here, we address the functions of the most commonGATA3mutation (X308_Splice) which generates a neoprotein that we designate as neoGATA3, associated with good patient prognosis. Based on extensive analyses of molecular and clinical data from approximately 3000 breast cancer patients, supported by mechanistic studiesin vitro, we show that neoGATA3 interferes with the transcriptional programs controlled by estrogen and progesterone rece…