Tracing tsunami signatures of thead551 andad1303 tsunamis at the Gulf of Kyparissia (Peloponnese, Greece) using direct pushin situsensing techniques combined with geophysical studies

Proteomics of Galápagos Marine Iguanas Links Function of Femoral Gland Proteins to the Immune System

Femoral glands secrete a wax-like substance on the inner side of lizard hind legs, which is thought to function as a mode of chemical communication. Though the minor volatile fraction is well studied, the major protein fraction remains enigmatic. Here, we use proteomics to analyze proteins in femoral gland secretions of the Galápagos marine iguana. Although we found no evidence for proteins and peptides involved in chemical communication, we found several immune-regulatory proteins which also demonstrate anti-microbial functions. Accordingly, we show that femoral gland proteins and peptides function as a barrier against microbial infection and may prevent the rapid degradation of volatile s…

Detection and localization of chamber tombs in the environs of ancient Olympia, Peloponnese, Greece, based on a combination of archaeological survey and geophysical prospection

NeoFox: annotating neoantigen candidates with neoantigen features

Abstract Summary The detection and prediction of true neoantigens is of great importance for the field of cancer immunotherapy. Wesearched the literature for proposed neoantigen features and integrated them into a toolbox called NEOantigen Feature toolbOX (NeoFox). NeoFox is an easy-to-use Python package that enables the annotation of neoantigen candidates with 16 neoantigen features. Availability and implementation NeoFox is freely available as an open source Python package released under the GNU General Public License (GPL) v3 license at https://github.com/TRON-Bioinformatics/neofox. Supplementary information Supplementary data are available at Bioinformatics online.

Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein.

Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Analysis of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein ki…

Sedimentological and geoarchaeological evidence of multiple tsunamigenic imprint on the Bay of Palairos-Pogonia (Akarnania, NW Greece)

Abstract This paper presents evidence of multiple tsunami impact on the Bay of Palairos-Pogonia, NW Greece, during the Holocene based on detailed geo-scientific studies. Altogether, 41 vibracores were drilled to detect high-energy influence in the stratigraphical record. Layers of coarse-grained allochthonous marine deposits were found intersecting autochthonous fine-grained back beach sediments in the Palairos coastal plain, on top of beach or marly bedrock units at Pogonia beach and along the Pogonia cliff section. High-energy deposits are associated with specific sedimentary structures such as fining upward sequences, rip up-clasts, basal erosional contact, bi- to multimodal grain size d…