0000000000586586
AUTHOR
Ignacio Garcia
Study of single top production at high energy electron positron colliders
The effect of single top production on the study of top quark pair production in future high energy electron--positron colliders is evaluated. The rate of the single top quark production process is sizeable throughout a large range of center-of-mass energies and cannot easily be distinguished from the dominant pair production process. We discuss the impact on the top quark mass extraction from a scan through the pair production threshold and the determination of top quark form factors in the continuum. These results advocate for the exploration of the inclusive $e^+e^-\rightarrow W^+bW^-\bar{b}$ process, that includes both top quark pair and single top quark production.
Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway.
Abstract Mechanisms have evolved that allow cells to detect signals and generate an appropriate response. The accuracy of these responses relies on the ability of cells to discriminate between signal and noise. How cells filter noise in signaling pathways is not well understood. We have analyzed noise suppression in the yeast pheromone signaling pathway. By combining synthetic genetic array screening, mass spectrometry and single-cell time-resolved microscopy, we discovered that the poorly characterized protein Kel1 serves as a major noise suppressor of the pathway. At the molecular level, Kel1 suppresses spontaneous activation of the pheromone response by inhibiting membrane recruitment of…