Transcriptomic and Genetic Associations between Alzheimer's Disease, Parkinson's Disease, and Cancer.
Simple Summary Epidemiological studies have identified a link between neurodegenerative disorders and a reduced risk of overall cancer. Increases and decreases in the risk of site-specific cancers have also been reported. However, it is still unknown whether these associations arise due to shared genetic and molecular factors or are explained by other phenomena (e.g., biases in epidemiological studies or the use of medication). In this study, we aimed to investigate the potential molecular, genetic, and pharmacological links between Alzheimer’s and Parkinson’s diseases and a large panel of 22 cancer types. To examine the overlapping involvement of genes and pathways, we obtained differentia…
A general framework for a class of non-linear approximations with applications to image restoration
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S0377042717301188 Este es el pre-print del siguiente artículo: Candela, V., Falcó, A. & Romero, PD. (2018). A general framework for a class of non-linear approximations with applications to image restoration. Journal of Computational and Applied Mathematics, vol. 330 (mar.), pp. 982-994, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.cam.2017.03.008 This is the pre-peer reviewed version of the following article: Candela, V., Falcó, A. & Romero, PD. (2018). A general framework for a class of non-linear approximations with applic…
Antioxidant activity of 5-FU and new fluorinated uracil derivates
The intake of antioxidants has increased in the last years in order to treat some pathologies associated with oxidative stress such as cancer, diabetes mellitus, atherosclerosis, myocardial infarction, acute pancreatitis, Parkinson's and Alzheimer's disease among others. In colorectal cancer, a widely antineoplastic drug used is the fluorinated uracil molecule 5-Fluorouracile (5-FU). The aim of this study is to assess the antioxidant capacity observed by the inhibition of lipid peroxidation by 5-FU and other fluorinated uracil derivates: 6-[Difluoro(phenyl)methyl]-3-(2,4,6-trifluorophenyl)pyrimidine-2,4(1H,3H)-dione (S-81), 3-[2-Chloroethyl]-6-[difluoro(phenyl)methyl]pyrimidine-2,4(1H,3H)-d…