0000000000587330

AUTHOR

Emma Muñoz-moreno

showing 2 related works from this author

Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study

2021

© The Author(s) 2021.

MaleHistologyDendritic spineInfralimbic cortexPrefrontal CortexNeuroimagingNeurofilamentRats Sprague-DawleyInfralimbic cortexWhite matterDorsal raphe nucleusPhenolsPiperidinesmedicineAnimalsPrefrontal cortexbiologyChemistryGeneral NeuroscienceDorsal raphe nucleusPsychotomimeticMagnetic Resonance ImagingAntidepressive AgentsRatsMyelin basic proteinMyelinizationmedicine.anatomical_structureFast-acting antidepressantbiology.proteinNMDA receptorOriginal ArticleKetamineAnatomyNeurosciencemedicine.drugBrain Structure and Function
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Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism

2021

Peripheral inputs to the brain continuously shape its function and can influence the formation of non-emotional memory, but the underlying mechanisms have not been fully understood. Cannabinoid type-1 receptors (CB1R), widely distributed in the organism, is a well-recognized player in memory performance, and its systemic modulation significantly influences memory function. By assessing non-emotional memory in mice, we have now found a relevant role of peripheral CB1R in the formation of persistent memory. Indeed, peripherally restricted CB1R antagonism by using AM6545 showed a mnemonic effect that was occluded in adrenalectomized mice, after peripheral adrenergic blockade, or when vagus ner…

NorepinephrineCannabinoid receptorDopamineChemistrymedicine.medical_treatmentmedicineAdrenergicLocus coeruleusCannabinoidHippocampal formationNeuroscienceBlockademedicine.drug
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