0000000000587584

AUTHOR

Josef Donnerer

showing 2 related works from this author

NEONATAL CAPSAICIN TREATMENT DOES NOT PREVENT SPLANCHNIC VASODILATATION IN PORTAL-HYPERTENSIVE RATS

1994

It has been suggested that the peripheral sensory neurons are involved in the splanchnic hemodynamic changes of portal hypertension. Therefore the influence of permanent ablation of sensory neurons by neonatal capsaicin pretreatment (50 mg/kg, subcutaneously) on the development of the hyperdynamic splanchnic circulation in portal-hypertensive rats was studied. In adulthood, portal hypertension was induced with partial portal vein ligation. In study 1, systemic and splanchnic hemodynamics were measured by means of a radiolabeled-microsphere technique in portal-hypertensive rats, under ketamine anesthesia, pretreated with capsaicin or vehicle. Mean arterial pressure, heart rate, cardiac index…

Malemedicine.medical_specialtyMean arterial pressureCalcitonin Gene-Related PeptidePortal venous pressureHemodynamicschemistry.chemical_compoundInternal medicineHypertension PortalmedicineAnimalsNeurons AfferentSplanchnic CirculationRats WistarHepatologySplanchnic Circulationbusiness.industryHemodynamicsmedicine.diseaseRatsmedicine.anatomical_structureEndocrinologyAnimals NewbornchemistryGastric MucosaRegional Blood FlowCapsaicinVascular resistancePortal hypertensionCapsaicinSplanchnicbusinessDigestive SystemDilatation Pathologic
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Capsaicin desensitization in vivo is inhibited by ruthenium red.

1990

The effect of systemic administration of Ruthenium Red on the excitatory and desensitizing effect of capsaicin was investigated in rats. Ruthenium Red was injected s.c. 30 min before capsaicin was administered. The excitatory effect of capsaicin on corneal, perivascular and visceral afferents was not influenced by treatment with Ruthenium Red. However, determination of the neuropeptide content and evoked neuropeptide release in peripheral organs and dorsal spinal cord 48 h after treatment showed that Ruthenium Red attenuated the 'desensitizing' effect of capsaicin at peripheral, but not at central, endings of primary afferents. On the other hand, a capsaicin-elicited autonomic reflex mediat…

inorganic chemicalsRuthenium redCalcitonin Gene-Related PeptideInjections SubcutaneousCentral nervous systemUrinary BladderNeuropeptideBlood PressurePharmacologySubstance PSynaptic Transmissionchemistry.chemical_compoundIn vivootorhinolaryngologic diseasesAutonomic reflexmedicineAnimalsNeurons AfferentPharmacologyNerve EndingsNeuronsChemistryNeuropeptidesRats Inbred StrainsRuthenium RedRatsmedicine.anatomical_structureCapsaicinAnesthesiaExcitatory postsynaptic potentiallipids (amino acids peptides and proteins)NeuronCapsaicinEuropean journal of pharmacology
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