0000000000593960

AUTHOR

Michael Gaßel

showing 2 related works from this author

Inside Cover: Inhibition of Eimeria tenella CDK-Related Kinase 2: From Target Identification to Lead Compounds (ChemMedChem 8/2010)

2010

PharmacologyVirtual screeningbiologyKinaseDrug discoveryOrganic Chemistrybiology.organism_classificationBiochemistryCombinatorial chemistryEimeriaBiochemistryCyclin-dependent kinaseDrug Discoverybiology.proteinMolecular MedicineGeneral Pharmacology Toxicology and PharmaceuticsChemMedChem
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Inhibition of Eimeria tenella CDK-related kinase 2: From target identification to lead compounds.

2010

Apicomplexan parasites encompass several human- and animal-pathogenic protozoans such as Plasmodium falciparum, Toxoplasma gondii, and Eimeria tenella. E. tenella causes coccidiosis, a disease that afflicts chickens, leading to tremendous economic losses to the global poultry industry. The considerable increase in drug resistance makes it necessary to develop new therapeutic strategies against this parasite. Cyclin-dependent kinases (CDKs) are key molecules in cell-cycle regulation and are therefore prominent target proteins in parasitic diseases. Bioinformatics analysis revealed four potential CDK-like proteins, of which one—E. tenella CDK-related kinase 2 (EtCRK2)—has already been charact…

Molecular Sequence DataProtozoan ProteinsBiochemistryEimeriaArticleAdenosine TriphosphateCyclin-dependent kinaseDrug Discoveryparasitic diseasesAnimalsHumansComputer SimulationHomology modelingAmino Acid SequenceGeneral Pharmacology Toxicology and PharmaceuticsProtein Kinase InhibitorsPharmacologyVirtual screeningBinding SitesbiologyDrug discoveryKinaseCoccidiosisOrganic ChemistryCyclin-dependent kinase 2Cyclin-Dependent Kinase 2Plasmodium falciparumbiology.organism_classificationMolecular biologyBiochemistrybiology.proteinMolecular MedicineBenzimidazolesChickensSequence AlignmentEimeria tenellaChemMedChem
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