0000000000594160
AUTHOR
V. Pratap Reddy Gajulapalli
Organocatalytic Asymmetric Synthesis of 2,3′-Connected Bis-Indolinones by Mannich Reactions of N-Acetylindolin-3-ones with Isatin N-Boc Ketimines
A highly diastereo- and enantioselective Mannich reaction of N-acetylindolin-3-ones with isatin N-Boc ketimines to form 2,3′-connected bis-indolinones is developed employing a low loading of a readily available bifunctional thiourea catalyst. The asymmetric synthesis connects two indolinones via a vic-diamine unit and generates two neighboring stereocenters.
CCDC 1543566: Experimental Crystal Structure Determination
Related Article: V. Pratap Reddy Gajulapalli, Ehsan Jafari, Dipti Sankar Kundu, Suruchi Mahajan, Anssi Peuronen, Kari Rissanen, Dieter Enders|2017|Synthesis|49|4986|doi:10.1055/s-0036-1590823