6533b826fe1ef96bd1283b32
RESEARCH PRODUCT
Organocatalytic Asymmetric Synthesis of 2,3′-Connected Bis-Indolinones by Mannich Reactions of N-Acetylindolin-3-ones with Isatin N-Boc Ketimines
Suruchi MahajanAnssi PeuronenKari RissanenV. Pratap Reddy GajulapalliDipti S. KunduEhsan JafariDieter Enderssubject
010405 organic chemistryStereochemistryIsatinOrganic ChemistryEnantioselective synthesis010402 general chemistry01 natural sciencesMedicinal chemistryCatalysis0104 chemical sciencesStereocenterchemistry.chemical_compoundchemistryThioureaOrganocatalysisDiamineBifunctionalMannich reactiondescription
A highly diastereo- and enantioselective Mannich reaction of N-acetylindolin-3-ones with isatin N-Boc ketimines to form 2,3′-connected bis-indolinones is developed employing a low loading of a readily available bifunctional thiourea catalyst. The asymmetric synthesis connects two indolinones via a vic-diamine unit and generates two neighboring stereocenters.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-08-01 | Synthesis |