0000000000594218

AUTHOR

Miguel Romero

showing 4 related works from this author

PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells

2014

Background and Purpose PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on insulin signalling in endothelial cells are not known. We analysed the effects of the PPARβ/δ (PPARβ) agonists, GW0742 and L165041, on impaired insulin signalling induced by high glucose in HUVECs and aortic and mesenteric arteries from diabetic rats. Experimental Approach Insulin-stimulated NO production, Akt-Ser 473 and eNOS-Ser 1177 phosphorylation, and reactive oxygen species (ROS) production were studied in HUVECs incubated in low- or high-glucose medium. Insulin-stimulated relaxations and protein phosphorylation in vessels from streptozotocin (STZ)-induced diabetic rat…

2. Zero hungerPharmacologymedicine.medical_specialtyPyruvate dehydrogenase kinaseInsulinmedicine.medical_treatmentPDK4Oxidative phosphorylationBiologyStreptozotocinmedicine.diseaseInsulin resistanceEndocrinologyInternal medicinemedicinePhosphorylationProtein phosphorylationmedicine.drugBritish Journal of Pharmacology
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Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure

2021

Producción Científica

medicine.medical_specialtyTransthoracic echocardiographyCorazón - Cirugíamedicine.medical_treatmentCardiology3205.01 Cardiologíalcsh:MedicineHeart valves - Diseases - diagnostic imaging030204 cardiovascular system & hematologyRight ventricular to pulmonary arterial couplingArticlePulmonary hypertension03 medical and health sciencesmitral valve repairtransthoracic echocardiography0302 clinical medicineInternal medicinepulmonary hypertensionmedicineMitraClipCorazón - Enfermedades030212 general & internal medicineMitral valve repairMitral regurgitationMitral valve - Diseases - ImagingProportional hazards modelbusiness.industryMitraClipmitral valve regurgitationlcsh:RGeneral MedicineCardiac surgerymedicine.disease3207.04 Patología CardiovascularPulmonary hypertensionHipertensión pulmonarBlood pressureEchocardiographyHeart failureCardiologyright ventricular to pulmonary arterial couplingHeart - DiseasesMitral valve regurgitationbusinessMitral valve repairMitral valve regurgitation
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Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endotheli…

2015

Endothelial dysfunction plays a key role in obesity-induced risk of cardiovascular disease. The aim of the present study was to analyze the effect of chronic peroxisome proliferator-activated receptor (PPAR)β/δ agonist GW0742 treatment on endothelial function in obese mice fed a high-fat diet (HFD).Five-week-old male mice were allocated to one of the following groups: control, control-treated (GW0742, 3 mg/kg per day, by oral gavage), HFD, HFD + GW0742, HFD + GSK0660 (1 mg/kg/day, intraperitoneal) or HFD-GW0742-GSK0660 and followed for 11 or 13 weeks. GW0742 administration to mice fed HFD prevented the gain of body weight, heart and kidney hypertrophy, and fat accumulation. The increase in …

Blood GlucoseMaleAgonistmedicine.medical_specialtyNitric Oxide Synthase Type IIIEndotheliumPhysiologymedicine.drug_classCaveolin 1Peroxisome proliferator-activated receptorThiophenesDiet High-FatGW0742MiceInsulin resistanceInternal medicineInternal MedicinemedicineAnimalsObesityPPAR deltaSulfonesEndothelial dysfunctionReceptorPPAR-betaAortachemistry.chemical_classificationInterleukin-6Tumor Necrosis Factor-alphabusiness.industryGlucose Tolerance TestPeroxisomemedicine.diseaseToll-Like Receptor 4VasodilationThiazolesEndocrinologymedicine.anatomical_structureAdipose TissuechemistryHypertensionAdiponectinEndothelium VascularInsulin ResistanceReactive Oxygen SpeciesCardiology and Cardiovascular MedicinebusinessJournal of Hypertension
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Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study

2020

Background: Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip&reg

medicine.medical_specialtylcsh:Medicine030204 cardiovascular system & hematologyMitraclipArticle03 medical and health sciences0302 clinical medicineInternal medicinemedicineIn patient030212 general & internal medicinecardiovascular diseasesFunctional mitral regurgitationEjection fractionVentricular functionbusiness.industryMitraCliplcsh:RGeneral Medicinetranscatheterleft ventricular ejection FractionPropensity score matchingCardiologycardiovascular systemObservational studyTranscatheter mitral valve repairbusinesscirculatory and respiratory physiologyfunctional mitral regurgitationJournal of Clinical Medicine
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