0000000000595523

AUTHOR

A'laa Gharra

showing 2 related works from this author

Screening for gastric cancer using exhaled breath samples.

2019

Abstract Background The aim was to derive a breath-based classifier for gastric cancer using a nanomaterial-based sensor array, and to validate it in a large screening population. Methods A new training algorithm for the diagnosis of gastric cancer was derived from previous breath samples from patients with gastric cancer and healthy controls in a clinical setting, and validated in a blinded manner in a screening population. Results The training algorithm was derived using breath samples from 99 patients with gastric cancer and 342 healthy controls, and validated in a population of 726 people. The calculated training set algorithm had 82 per cent sensitivity, 78 per cent specificity and 79 …

AdultMalemedicine.medical_specialtyPopulationEarly detectionCancer detectionGastroenterologySensitivity and Specificity03 medical and health sciences0302 clinical medicineStomach NeoplasmsInternal medicineMedicineHumansMass Screeningeducation030304 developmental biology0303 health scienceseducation.field_of_studyTraining setbusiness.industryConfoundingCase-control studyReproducibility of ResultsMiddle AgedBreath Tests030220 oncology & carcinogenesisCase-Control StudiesSurgerybusinessAlgorithmsThe British journal of surgery
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Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules.

2016

We report on an artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath. The performance of this artificially intelligent nanoarray was clinically assessed on breath samples collected from 1404 subjects having one of 17 different disease conditions included in the study or having no evidence of any disease (healthy controls). Blind experiments showed that 86% accuracy could be achieved with the artificially intelligent nanoarray, allowing both detection and discrimination between the different disease conditions examined.…

AdultMalevolatile organic compounddiagnosisGeneral Physics and AstronomyPattern analysisMetal NanoparticlesNanotechnology02 engineering and technologyBiosensing Techniques01 natural sciencesArticlePattern Recognition AutomatedArtificial IntelligencesensornoninvasiveMedicineHumansGeneral Materials Sciencecarbon nanotubeVolatile Organic Compoundsdiseasebreathbusiness.industryNanotubes Carbonnanoparticle010401 analytical chemistryGeneral EngineeringPattern recognitionMiddle Aged021001 nanoscience & nanotechnology0104 chemical sciences3. Good healthBreath TestsCase-Control StudiesFemaleArtificial intelligenceGold0210 nano-technologybusinessACS nano
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