Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations.
Primary triple-negative invasive lobular breast carcinomas (TN-ILCs), which do not express hormone receptors and HER2 at diagnosis, are rare and poorly known. In this study, we analyzed the largest TN-ILC series ever reported in the literature, in comparison to phenotypically similar breast tumor subtypes: triple-negative invasive ductal carcinoma (TN-IDC) and hormone receptor-positive invasive lobular carcinoma (HR + ILC). All primary TN-ILCs registered in our database between 2000 and 2018 (n = 38) were compared to tumors from control groups, matched by stage and Elston/Ellis grade, with regard to clinical, pathologic, and immunohistochemical characteristics. A comparative molecular analy…
Terahertz Biomedical Imaging: From Multivariate Analysis and Detection to Material Parameter Extraction
Terahertz imaging is an interesting route for biomedical analysis. In particular, cancer imaging is a subject of study for different teams [1,2]. A work is done in Bordeaux in partnership with a hospital to do terahertz analysis of breast tissue. This work is done in reflection with time domain imaging setup with fresh samples. The aim is to accurately assess tumor margins and which could in the future allow a quick validation of the precision of the surgical procedure and know if new surgery should be performed. We have presented in a previous paper [3] the use of automatic methods of image generation with different parameters [4] in order to explore the different contrasts that exist in t…