0000000000595998

AUTHOR

Silvia Ferrari

showing 6 related works from this author

Harnessing mechanosensation in next generation cardiovascular tissue engineering

2020

The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufact…

0301 basic medicineComputer sciencelcsh:QR1-502Review030204 cardiovascular system & hematologyBiochemistryCardiovascular SystemMechanotransduction Cellularlcsh:MicrobiologyCardiac regeneration03 medical and health sciences0302 clinical medicineTissue engineeringMechanosensingExtracellularAnimalsHumansMolecular BiologyTissue homeostasisMechanosensationTissue EngineeringExtracellular Matrix030104 developmental biologyCardiac regenerationNeuroscienceIntracellular
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Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from th…

2016

[Background] To report on long-term results of a phase 3 trial comparing three versus five cycles of adjuvant chemotherapy (CT) with full-dose epirubicin+ifosfamide in high-risk soft tissue sarcomas (STS).

LeiomyosarcomaMale0301 basic medicinesarcomaSurvivalmedicine.medical_treatment0302 clinical medicineRisk FactorsQuality of surgeryNeoadjuvant therapySoft tissue sarcomaIfosfamideresponseSoft tissue sarcomaResponseSarcomaHematologyMiddle AgedPrognosisadjuvant chemotherapyTreatment OutcomeOncologyChemotherapy Adjuvant030220 oncology & carcinogenesissoft tissue sarcomaFemaleSarcomaadjuvant chemotherapy; quality of surgery; response; sarcoma; soft tissue sarcoma; survivalmedicine.drugEpirubicinAdultLeiomyosarcomamedicine.medical_specialtyPreoperative caresurvivalDisease-Free Survival03 medical and health sciencesmedicineHumansAgedbusiness.industrymedicine.diseaseSurgeryAdjuvant chemotherapyRegimen030104 developmental biologybusinessquality of surgeryFollow-Up Studies
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Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression.

2014

ABSTRACT Background At diagnosis, identification of reliable biological indicators of prognosis to allow stratification of patients according to different risks is an important but still unresolved aspect in the treatment of Ewing sarcoma (EWS) patients. This study aimed to explore the role of miR-34A expression on prognosis of EWS patients. Patients and methods Specimens from 109 patients with non-metastatic EWS treated at the Rizzoli Institute with neoadjuvant chemotherapy (protocols ISG/SSGIII, EW-1, EW-2, EW-REN2, EW-REN3, EW-PILOT) and 17 metastases were studied. Sixty-eight patients (62%) remained disease-free and 41 (38%) relapsed (median follow-up: 67 months, range 9–241 months). Ex…

AdultMalePrognosiHydro-Lyasemedicine.medical_treatmentSarcoma EwingDisease-Free SurvivalCyclin D1medicineHumansCyclin D1Neoplasm Metastasisprognostic biomarkerNeoadjuvant therapyHydro-LyasesAged 80 and overTissue microarraybiologybusiness.industryProportional hazards modelMedicine (all)Ewing's sarcomaMicroRNAHematologyMiddle Agedmedicine.diseasePrognosisNeoadjuvant TherapyNeoplasm MetastasiGene Expression Regulation NeoplasticMicroRNAsKi-67 AntigenTreatment OutcomeOncologyDrug Resistance NeoplasmKi-67biology.proteinCancer researchKi-67ImmunohistochemistryFemaleSarcomacyclin D1; Ewing sarcoma; Ki-67; miR-34a; prognostic biomarkers; Adult; Aged 80 and over; Cyclin D1; Disease-Free Survival; Drug Resistance Neoplasm; Female; Gene Expression Regulation Neoplastic; Humans; Hydro-Lyases; Ki-67 Antigen; Male; MicroRNAs; Middle Aged; Neoadjuvant Therapy; Neoplasm Metastasis; Prognosis; Sarcoma Ewing; Treatment Outcome; Medicine (all)businessEwing sarcomamiR-34aHumanAnnals of oncology : official journal of the European Society for Medical Oncology
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First-episode psychosis and migration in Italy (PEP-Ita migration): A study in the Italian mental health services

2014

Abstract Background It has been frequently reported a higher incidence of psychotic disorders in immigrants than in native populations. There is, however, a lack of knowledge about risk factors which may explain this phenomenon. A better understanding of the causes of psychosis among first-generation migrants is highly needed, particularly in Italy, a country with a recent massive migration. Methods/Design The “Italian study on first-episode psychosis and migration (PEP-Ita)” is a prospective observational study over a two-year period (1 January 2012–31 December 2013) which will be carried out in 11 Italian mental health centres. All participating centres will collect data about all new cas…

MaleImmigrationEthnic groupStudy ProtocolEthnicitySettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.Prospective Studies10. No inequalitymedia_commonFirst-episode psychosis; Italy; Migrants; Protective factors; Risk factorsTransients and Migrantseducation.field_of_studyProtective factorIncidenceMiddle AgedFirst-episode psychosisPsychiatry and Mental healthMental HealthItaly8. Economic growthFemalePsychopathologyAdultMental Health Servicesmedicine.medical_specialtyPsychosisAdolescentmedia_common.quotation_subjectPopulationEmigrants and ImmigrantsMigrants First-episode psychosis Italy Risk factors Protective factorsMigrantsYoung AdultFirst-episode psychosiIntervention (counseling)medicineHumansPsychiatryeducationSettore MED/25 - Psichiatriabusiness.industryMigrantmedicine.diseaseMental healthProtective factorsRisk factorsPsychotic DisordersObservational studybusiness
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Burnout syndrome among psychiatric trainees in 22 countries: Risk increased by long working hours, lack of supervision, and psychiatry not being firs…

2016

AbstractBackgroundPostgraduate medical trainees experience high rates of burnout, but evidence regarding psychiatric trainees is missing. We aim to determine burnout rates among psychiatric trainees, and identify individual, educational and work-related factors associated with severe burnout.MethodsIn an online survey psychiatric trainees from 22 countries were asked to complete the Maslach Burnout Inventory (MBI-GS) and provide information on individual, educational and work-related parameters. Linear mixed models were used to predict the MBI-GS scores, and a generalized linear mixed model to predict severe burnout.ResultsThis is the largest study on burnout and training conditions among p…

Working hoursAdultMaleMental Health ServicesComplete datamedicine.medical_specialtyBurnout; Psychiatry; Risk factors; Supervision; Training; Adult; Career Choice; Demography; Education Medical Continuing; Female; Humans; Male; Mental Health Services; Middle Aged; Personality Inventory; Psychiatry; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Work Schedule Tolerance; Burnout Professional; Psychiatry and Mental HealthPersonality Inventoryhealth care facilities manpower and servicesBurnout syndromeeducationBurnout03 medical and health sciences0302 clinical medicineRisk FactorsSurveys and QuestionnairesWork Schedule TolerancemedicineHumans030212 general & internal medicinePsychiatryBurnout ProfessionalDemographyHigh rateResponse rate (survey)PsychiatryCareer Choicebusiness.industryMiddle Aged030227 psychiatryPsychiatry and Mental healthSocioeconomic FactorsEducation Medical ContinuingFemalePersonality Assessment Inventorybusinesspsychological phenomena and processesCareer choiceClinical psychologyEuropean psychiatry : the journal of the Association of European Psychiatrists
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Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation

2022

Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response of these cells to mechanical cues through activation of the Hippo transcriptional pathway. The objective of the present study was to assess the role of cellular/nuclear straining forces acting in myofibroblast differentiation of cardiac stromal cells under the control of YAP (yes-associated protein) transcription factor and to validate this finding using a pharmacological agent that interf…

Transcriptional ActivationPhysiologyfibrosismyofibroblastsVerteporfinheart failureYAP-Signaling ProteinsSettore MED/11 - Malattie dell'Apparato CardiovascolareSettore MED/23 - Chirurgia Cardiacafibrosis; heart failure; myofibroblasts; stromal cell; transcription factorsstromal cellPhosphoproteinscell mechanics; fibrosis; heart failure; myofibroblasts; stromal cell; YAP transcription factor;MiceYAP transcription factorcell mechanicsSettore CHIM/09 - Farmaceutico Tecnologico Applicativotranscription factorsTrans-ActivatorsAnimalsHumansCardiology and Cardiovascular MedicineAdaptor Proteins Signal Transducing
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