6533b826fe1ef96bd1283ee9
RESEARCH PRODUCT
Harnessing mechanosensation in next generation cardiovascular tissue engineering
Maurizio PesceGloria GaroffoloStefano RizziMarianna BarbutoSilvia FerrariGiacomo Bernavasubject
0301 basic medicineComputer sciencelcsh:QR1-502Review030204 cardiovascular system & hematologyBiochemistryCardiovascular SystemMechanotransduction Cellularlcsh:MicrobiologyCardiac regeneration03 medical and health sciences0302 clinical medicineTissue engineeringMechanosensingExtracellularAnimalsHumansMolecular BiologyTissue homeostasisMechanosensationTissue EngineeringExtracellular Matrix030104 developmental biologyCardiac regenerationNeuroscienceIntracellulardescription
The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufacturing criteria for a next generation of cardiovascular tissue implants.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-10-07 |