Chapter 4 3D brainstem topodiagnosis – a voxel-based model analyzing MR imaging data

Publisher Summary This chapter presents a new method of statistically based three-dimensional (3D) brainstem mapping to identify brainstem structures responsible for specific clinical and electrophysiological abnormalities. To ensure reliable correlations, a large cohort of patients with magnetic resonance (MR)-documented brainstem infarctions were recruited in two European neurological institutions—namely, the Department of Neurology, Johannes Gutenberg University, Mainz, Germany, and the Department of Neurological Sciences, “La Sapienza” University of Rome, Italy. This method minimizes the risk of highlighting vascular territories rather than the structures specifically responsible for th…