0000000000598425

AUTHOR

Desiree Barato

showing 4 related works from this author

The effect of different periods of argon deaeration on exhaled breath condensate pH.

2011

Exhaled breath condensate (EBC) pH has been considered as a biomarker of airway inflammation in asthma. However, little information is available on the duration of argon deaeration required to achieve a stable pH in EBC samples.To identify differences in EBC pH after argon deaeration for 2, 4, and 8 min.EBC pH was determined in EBC samples from 48 subjects with allergic rhinitis (11 asthmatics) and 14 healthy volunteers without deaeration and after argon deaeration for 2, 4, and 8 min.The mean (95% CI) pH values obtained from samples analyzed after 4 min [7.66 (7.52-7.80)] and 8 min [7.70 (7.55-7.85)] of argon deaeration were significantly less acidic (p.001) than those identified after 2 m…

Pulmonary and Respiratory MedicineAdultMalemedicine.medical_specialtyGastroenterologyMean differenceDrug Administration ScheduleInternal medicineHealthy volunteersmedicineHypersensitivityImmunology and AllergyHumansExhaled breath condensateArgonAsthmaRhinitisbusiness.industryAirway inflammationHydrogen-Ion Concentrationmedicine.diseaseBreath TestsAnesthesiaPediatrics Perinatology and Child HealthBiomarker (medicine)FemalebusinessBiomarkersThe Journal of asthma : official journal of the Association for the Care of Asthma
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Effects of allergen exposure on methacholine and AMP-induced air trapping in pollen-sensitive subjects

2011

Summary Background The effect of pro-inflammatory stimuli on bronchoconstrictor-induced air trapping has not been studied. Objective To determine the effect of natural allergen exposure, a pro-inflammatory stimulus, on methacholine- and adenosine 5′-monophospate (AMP)-induced air trapping. Methods Airway responsiveness to methacholine and AMP before and during the pollen season was obtained in 25 subjects with pollen allergy and in 10 healthy controls. The response was expressed by the sensitivity (PC 20 value) and by the slope and intercept of the FVC values recorded at each step of the challenge against the corresponding FEV 1 values. Results The slope and intercept FVC versus FEV 1 value…

AdultMaleAdenosine monophosphatePulmonary and Respiratory Medicinemedicine.medical_specialtyAllergyBronchoconstrictionVital Capacitymedicine.disease_causeAir trappingBronchial Provocation TestsAirway responsivenesschemistry.chemical_compoundFEV1/FVC ratioAllergenForced Expiratory VolumeInternal medicinePollenotorhinolaryngologic diseasesmedicineHumansMethacholinebusiness.industryRhinitis Allergic SeasonalMiddle AgedAllergensrespiratory systemmedicine.diseaseAdenosine MonophosphateAsthmaAir trappingrespiratory tract diseasesEndocrinologyAdenosine 5’-monophosphatechemistrySpirometryImmunologyPollenFemaleMethacholineBronchial Hyperreactivitymedicine.symptomALLERGEN EXPOSUREbusinesscirculatory and respiratory physiologymedicine.drugRespiratory Medicine
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Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methac…

2009

Background The effect of adenosine monophosphate (AMP) on forced vital capacity (FVC) has never been systematically investigated. Objective To compare methacholine- and AMP-induced changes in FVC, as a marker of air trapping, in asthmatic patients treated and not treated with inhaled corticosteroids (ICSs). Methods Airway responsiveness to equipotent concentrations of AMP and methacholine was obtained in asthmatic patients treated (n = 32) and not treated (n = 18) with ICSs. The response was expressed by the provocation concentration of agonist that caused a decrease in forced expiratory volume in 1 second (FEV 1 ) of 20% (PC 20 ) and by the slope of the FVC values recorded at each step of …

Pulmonary and Respiratory MedicineAgonistAdultMalemedicine.medical_specialtyVital capacityAdolescentmedicine.drug_classBronchoconstrictionImmunologyProvocation testVital CapacityBronchial Provocation TestsFEV1/FVC ratioYoung AdultAdrenal Cortex HormonesInternal medicineForced Expiratory VolumeAdministration InhalationmedicineImmunology and AllergyHumansMethacholine ChlorideAsthmaAgedInhalationbusiness.industryrespiratory systemMiddle Agedmedicine.diseaseAdenosine MonophosphateAsthmarespiratory tract diseasesEndocrinologyBronchoconstrictionMethacholineFemalemedicine.symptombusinessmedicine.drugAnnals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology
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The effect of challenge method on methacholine-induced changes in sensitivity and air trapping

2010

Summary Background The methacholine challenge test performed with the tidal breathing method induces a greater fall in FEV 1 than the dosimeter method; however, the effect of the challenge method on methacholine-induced fall in FVC has not been investigated. Objective To determine the influence of the challenge method on methacholine-induced changes in FEV 1 and FVC. Methods Airway responsiveness to methacholine was determined by dosimeter method and tidal breathing method in 37 subjects with suspected asthma. The dosimeter was modified to deliver an identical volume to that obtained with the tidal breathing method and the same nebulizer model was used for the two challenges. The response w…

AdultMalePulmonary and Respiratory MedicineRespiratory mechanicsVital CapacityAir trappingAirway responsivenessBronchoconstrictor AgentsFEV1/FVC ratioForced Expiratory VolumemedicineHumansMethacholine ChlorideAsthmaCross-Over StudiesDosimeterMethacholineDose-Response Relationship DrugInhalationbusiness.industryrespiratory systemmedicine.diseaseFVCAsthmaRespiratory Function Testsrespiratory tract diseasesNebulizerAnesthesiaFemaleMethacholineGeometric meanmedicine.symptombusinesscirculatory and respiratory physiologymedicine.drugRespiratory Medicine
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