0000000000599531
AUTHOR
Laura Soler-calero
Mn(II) complexes of scorpiand-like ligands. A model for the MnSOD active centre with high in vitro and in vivo activity
Manganese complexes of polyamines consisting of an aza-pyridinophane macrocyclic core functionalised with side chains containing quinoline or pyridine units have been characterised by a variety of solution techniques and single crystal x-ray diffraction. Some of these compounds have proved to display interesting antioxidant capabilities in vitro and in vivo in prokaryotic (bacteria) and eukaryotic (yeast and fish embryo) organisms. In particular, the Mn complex of the ligand containing a 4-quinoline group in its side arm which, as it happens in the MnSOD enzymes, has a water molecule coordinated to the metal ion that shows the lowest toxicity and highest functional efficiency both in vitro …
CCDC 1020483: Experimental Crystal Structure Determination
Related Article: M. Paz Claresa, Carolina Serena, Salvador Blasco, Aida Nebot, Lucas del Castillo, Conxa Soriano, Antonio Domènech, Ana Virginia Sánchez-Sánchez, Laura Soler-Calero, José Luis Mullor, Antonio García-España, Enrique García-España|2015|J.Inorg.Biochem.|143|1|doi:10.1016/j.jinorgbio.2014.11.001
CCDC 999624: Experimental Crystal Structure Determination
Related Article: M. Paz Claresa, Carolina Serena, Salvador Blasco, Aida Nebot, Lucas del Castillo, Conxa Soriano, Antonio Domènech, Ana Virginia Sánchez-Sánchez, Laura Soler-Calero, José Luis Mullor, Antonio García-España, Enrique García-España|2015|J.Inorg.Biochem.|143|1|doi:10.1016/j.jinorgbio.2014.11.001