6533b826fe1ef96bd1284830
RESEARCH PRODUCT
Mn(II) complexes of scorpiand-like ligands. A model for the MnSOD active centre with high in vitro and in vivo activity
Carolina SerenaConxa SorianoLaura Soler-caleroSalvador BlascoAida NebotAna V. Sánchez-sánchezLucas Del CastilloM. Paz ClaresAntonio Garcia-españaJosé L. MullorEnrique García-españaAntonio Doménechsubject
Fish ProteinsSaccharomyces cerevisiae ProteinsStereochemistryOryziasSaccharomyces cerevisiaeLigandsFish embryo modelsBiochemistryAntioxidantsInorganic Chemistrychemistry.chemical_compoundAntioxidant activityIn vivoCatalytic DomainPyridineSide chainEscherichia coliAnimalschemistry.chemical_classificationManganeseBacteriaLigandSuperoxide DismutaseEscherichia coli ProteinsQuinolineYeastIn vitroYeastMn(II) complexesEnzymechemistryModels ChemicalPolyazamacrocyclic scorpiandsQuinolinesdescription
Manganese complexes of polyamines consisting of an aza-pyridinophane macrocyclic core functionalised with side chains containing quinoline or pyridine units have been characterised by a variety of solution techniques and single crystal x-ray diffraction. Some of these compounds have proved to display interesting antioxidant capabilities in vitro and in vivo in prokaryotic (bacteria) and eukaryotic (yeast and fish embryo) organisms. In particular, the Mn complex of the ligand containing a 4-quinoline group in its side arm which, as it happens in the MnSOD enzymes, has a water molecule coordinated to the metal ion that shows the lowest toxicity and highest functional efficiency both in vitro and in vivo. (C) 2014 Elsevier Inc. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |