Author: Lucas Del Castillo

0000000000462046

AUTHOR

Lucas Del Castillo

In vitro fungicidal activities of echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis evaluated by time-kill studies.

ABSTRACT Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis , C. orthopsilosis , and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (−0.06 to −0.05 CFU/ml/h) for C. metapsilosis and C. orthopsilosis rather than for C. parapsilosis (mean MICs, 0.59 to 1.68 mg/liter). Micafungin and anidulafungin killing rates were greater than those determined for caspofungin. None of the echinocandins had fungicidal activity against C. parapsilosis .

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Mn(II) complexes of scorpiand-like ligands. A model for the MnSOD active centre with high in vitro and in vivo activity

Manganese complexes of polyamines consisting of an aza-pyridinophane macrocyclic core functionalised with side chains containing quinoline or pyridine units have been characterised by a variety of solution techniques and single crystal x-ray diffraction. Some of these compounds have proved to display interesting antioxidant capabilities in vitro and in vivo in prokaryotic (bacteria) and eukaryotic (yeast and fish embryo) organisms. In particular, the Mn complex of the ligand containing a 4-quinoline group in its side arm which, as it happens in the MnSOD enzymes, has a water molecule coordinated to the metal ion that shows the lowest toxicity and highest functional efficiency both in vitro …

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Genotoxic Potential of N ‐(Benzothiazolyl)sulfonamide Copper(II) Complexes on Yeast Cells Transformed with YEGFP Expression Constructs Containing the RAD54 or RNR2 Promoter

Four ternary complexes [Cu(L)2(phen)] where L is an N(benzothiazol-2-yl)sulfonamide derivative have been prepared and their ability to cleave DNA has been studied. The complexes were structurally characterized with the aid of single-crystal X-ray crystallography. Whereas the molecular structure of the [Cu(L1)2(phen)] (1) [HL1 = N-(6-chlorobenzothiazol-2-yl)benzenesulfonamide] and [Cu(L3)2(phen)] (3) [HL3 = N-(benzothiazol-2-yl)benzenesulfonamide] complexes can best be described as having a distorted squareplanar geometry, that of the [Cu(L4)2(phen)] (4) [HL4 = N(benzothiazol-2-yl)toluenesulfonamide] complex shows a strictly square-planar geometry. The [Cu(L2)2(phen)MeOH] (2) [HL2 = N-(6-chl…

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CCDC 1020483: Experimental Crystal Structure Determination

Related Article: M. Paz Claresa, Carolina Serena, Salvador Blasco, Aida Nebot, Lucas del Castillo, Conxa Soriano, Antonio Domènech, Ana Virginia Sánchez-Sánchez, Laura Soler-Calero, José Luis Mullor, Antonio García-España, Enrique García-España|2015|J.Inorg.Biochem.|143|1|doi:10.1016/j.jinorgbio.2014.11.001

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CCDC 999624: Experimental Crystal Structure Determination

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