6533b820fe1ef96bd127922c

RESEARCH PRODUCT

In vitro fungicidal activities of echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis evaluated by time-kill studies.

Javier PemánEmilia CantónAna Espinel-ingroffLucas Del Castillo

subject

Microbiological TechniquesAntifungal AgentsTime FactorsMicrobial Sensitivity TestsIn Vitro TechniquesAnidulafunginMicrobiologychemistry.chemical_compoundEchinocandinsLipopeptidesCandida metapsilosisCaspofunginmedicinepolycyclic compoundsPharmacology (medical)CandidaPharmacologybiologyMicafunginFungi imperfectibiology.organism_classificationbacterial infections and mycosesIn vitroFungicideInfectious DiseaseschemistrySusceptibilityMicafunginAnidulafunginCaspofunginEchinocandinsmedicine.drug

description

ABSTRACT Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis , C. orthopsilosis , and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (−0.06 to −0.05 CFU/ml/h) for C. metapsilosis and C. orthopsilosis rather than for C. parapsilosis (mean MICs, 0.59 to 1.68 mg/liter). Micafungin and anidulafungin killing rates were greater than those determined for caspofungin. None of the echinocandins had fungicidal activity against C. parapsilosis .

yearjournalcountryeditionlanguage
2010-05-01Antimicrobial agents and chemotherapy
10.1128/aac.01538-09https://pubmed.ncbi.nlm.nih.gov/20145083