0000000000599803
AUTHOR
Sebastian Jäger
Flavor physics in the quark sector
218 páginas, 106 figuras, 89 tablas.-- arXiv:0907.5386v2.-- Report of the CKM workshop, Rome 9-13th Sep. 2008.-- et al.
Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein
Ectodomain shedding of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer disease amyloid beta peptide (Abeta). The molecular mechanisms underlying the control of APP shedding remain little understood but are in part dependent on the low density lipoprotein receptor-related protein (LRP), which is involved in APP endocytosis. Here, we show that the APP homolog APLP1 (amyloid precursor-like protein 1) influences APP shedding. In human embryonic kidney 293 cells expression of APLP1 strongly activated APP shedding by alpha-secretase and slightly reduced beta-secretase cleavage. As revealed by domain deletion analysis, the increase in APP shedding re…
Reassessing the discovery potential of theB→K*ℓ+ℓ−decays in the large-recoil region: SM challenges and BSM opportunities
We critically examine the potential to disentangle the Standard Model (SM) and new physics (NP) in $B\ensuremath{\rightarrow}{K}^{*}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ and $B\ensuremath{\rightarrow}{K}^{*}{e}^{+}{e}^{\ensuremath{-}}$ decays, focusing on (i) the LHCb anomaly, (ii) the search for right-handed currents, and (iii) lepton-universality violation. Restricting ourselves to the large-recoil region, we advocate a parametrization of the hadronic matrix elements that separates model-independent information about nonperturbative QCD from the results of model calculations. We clarify how to estimate corrections to the heavy-quark limit that would generate a right-h…
Reassessing the discovery potential of the $B \to K^{*} \ell^+\ell^-$ decays in the large-recoil region: SM challenges and BSM opportunities
We critically examine the potential to disentangle Standard Model (SM) and New Physics (NP) in $B \to K^* \mu^+\mu^-$ and $B\to K^* e^+ e^-$ decays, focusing on $(i)$ the LHCb anomaly, $(ii)$ the search for right-handed currents, and $(iii)$ lepton-universality violation. Restricting ourselves to the large-recoil region, we advocate a parameterisation of the hadronic matrix elements that separates model-independent information about nonperturbative QCD from the results of model calculations. We clarify how to estimate corrections to the heavy-quark limit that would generate a right-handed (virtual) photon in the $b\to s\gamma$ contribution to the decay. We then apply this approach to the di…
α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
The Swedish mutation within the amyloid precursor protein (APP) causes early-onset Alzheimer's disease due to increased cleavage of APP by BACE1. While beta-secretase shedding of Swedish APP (APPswe) largely results from an activity localized in the late secretory pathway, cleavage of wild-type APP occurs mainly in endocytic compartments. However, we show that liberation of Abeta from APPswe is still dependent on functional internalization from the cell surface. Inspite the unchanged overall beta-secretase cleaved soluble APP released from APP(swe) secretion, mutations of the APPswe internalization motif strongly reduced C99 levels and substantially decreased Abeta secretion. We point out t…