Validating graph-based connectivity models using independent presence/absence and genetic datasets.

Validation des modèles de connectivité issus de la théorie des graphes en utilisant des données génétiques

National audience; Modéliser la connectivité fonctionnelle des habitats est déterminant pour la conservation de la biodiversité. Les graphes paysagers, en modélisant des taches d’habitat reliées par des chemins de dispersion potentiels, permettent de quantifier la connectivité du paysage. Si cette approche semble prometteuse, sa validité écologique reste à démontrer. Tester sa validité implique de confronter des données de connectivité issues d’un graphe à des données reflétant la dispersion des individus, telles que des données génétiques. Dans cet objectif, nous avons modélisé la connectivité de l’habitat d’une espèce d’oiseau forestière, la Paruline caféiette (Setophaga plumbea), en Guad…

Life history adjustments to intestinal inflammation in a gut nematode.

ABSTRACT Many parasitic nematodes establish chronic infections. This implies a finely tuned interaction with the host immune response in order to avoid infection clearance. Although a number of immune interference mechanisms have been described in nematodes, how parasites adapt to the immune environment provided by their hosts remains largely unexplored. Here, we used the gastrointestinal nematode Heligmosomoides polygyrus to investigate the plasticity of life history traits and immunomodulatory mechanisms in response to intestinal inflammation. We adopted an experimental model of induced colitis and exposed worms to intestinal inflammation at two different developmental stages (larvae and …

Validation of graph-based connectivity models using genetic data.

Modelling the functional connectivity of habitats is crucial for biodiversity conservation. By modelling potential dispersal paths among habitat patches, landscape graphs are often used to quantify landscape connectivity. While this approach seems promising, it often lacks biological validation. To ensure its ecological relevance, we assessed the ability of connectivity metrics calculated from landscape graphs to predict population genetic structure that closely reflects the dispersal of individuals, and thus functional connectivity. We modelled the habitat network of a forest bird species (Plumbeous warbler, Setophaga plumbea) in Guadeloupe using three graphs constructed either from expert…

Disentangling the effect of host genetics and gut microbiota on resistance to an intestinal parasite

11 pages; International audience; Resistance to infection is a multifactorial trait, and recent work has suggested that the gut microbiota can also contribute to resistance. Here, we performed a fecal microbiota transplant to disentangle the contribution of the gut microbiota and host genetics as drivers of resistance to the intestinal nematode Heligmosomoides polygyrus. We transplanted the microbiota of a strain of mice (SJL), resistant to H. polygyrus, into a susceptible strain (CBA) and vice-versa. We predicted that if the microbiota shapes resistance to H. polygyrus, the FMT should reverse the pattern of resistance between the two host strains. The two host strains had different microbi…

Data from: Life-history adjustments to intestinal inflammation in a gut nematode

Many parasitic nematodes establish chronic infections. This implies a finely tuned interaction with the host immune response in order to avoid infection clearance. While a number of immune interference mechanisms have been described in nematodes, how parasites adapt to the immune environment provided by their hosts remains largely unexplored. Here, we used the gastrointestinal nematode Heligmosomoides polygyrus to investigate the plasticity of life history traits and immunomodulatory mechanisms in response to intestinal inflammation. We adopted an experimental model of induced colitis and exposed worms to intestinal inflammation at two different developmental stages (larvae and adults). We …