0000000000605847

AUTHOR

Fabio

showing 4 related works from this author

Valorization of apple peels through the study of the effects on the amyloid aggregation process of ?-casein

2021

Waste valorization represents one of the main social challenges when promoting a circular economy and environmental sustainability. Here, we evaluated the effect of the polyphenols extracted from apple peels, normally disposed of as waste, on the amyloid aggregation process of ?-casein from bovine milk, a well-used amyloidogenic model system. The effect of the apple peel extract on protein aggregation was examined using a thioflavin T fluorescence assay, Congo red binding assay, circular dichroism, light scattering, and atomic force microscopy. We found that the phenolic extract from the peel of apples of the cultivar "Fuji", cultivated in Sicily (Caltavuturo, Italy), inhibited ?-casein fib…

Circular dichroismMalusAmyloidAmyloidSettore CHIM/10 - Chimica Degli Alimenti&#954INHIBITIONPharmaceutical ScienceOrganic chemistryPROTEINProtein aggregationMicroscopy Atomic ForceFIBRIL FORMATIONArticleAnalytical Chemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicineQD241-441OLIGOMERSCaseinTRANSTHYRETIN AMYLOIDOSISANTIOXIDANTDrug Discovery-casein amyloid aggregationFood sciencePhysical and Theoretical Chemistrypolyphenolic extract030304 developmental biology0303 health sciencesbiologyChemistryNATURAL POLYPHENOLSCaseinsκ-casein amyloid aggregationbiology.organism_classificationSTATECongo redfruit wasteChemistry (miscellaneous)PolyphenolFIBRILLOGENESISMalusFruit waste; Polyphenolic extract; ?-casein amyloid aggregationMolecular MedicineThioflavinTHIOFLAVIN-T030217 neurology & neurosurgery
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A new replacement name for the fossil spider Veterator Petrunkevitch, 1963 (Arthropoda: Arachnida: Araneae)

2021

A junior homonym was detected in the genera of fossil Araneae and the following replacement name is proposed within the family Trochanteriidae: Neoveterator Ceccolini & Cianferoni nom. nov. pro Veterator Petrunkevitch, 1963 nec Laws, 1944. Eight new combinations (comb. nov.) are proposed.

combinatio nova fossil araneae nomen novum replacement nameSpiderbiologyNomen novumPaleontologyZoologyTrochanteriidaebiology.organism_classificationQE701-760Homonym (biology)Combinatio novaNomen novumReplacement nameFossil Araneae
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Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases?

2020

Brominated flame-retardant (BFRs) exposure promotes multiple adverse health outcomes involved in oxidative stress, inflammation, and tissues damage. We investigated BFR effects, known as polybrominated diphenyl ethers (PBDEs) (47, 99 and 209) in an air-liquid-interface (ALI) airway tissue derived from A549 cell line, and compared with ALI culture of primary human bronchial epithelial cells (pHBEC). The cells, exposed to PBDEs (47, 99 and 209) (0.01-1 mu M) for 24 h, were studied for IL-8, Muc5AC and Muc5B (mRNAs and proteins) production, as well as NOX-4 (mRNA) expression. Furthermore, we evaluated tight junction (TJ) integrity by Trans-Epithelial Electrical Resistance (TEER) measurements, …

Lung DiseasesHealth Toxicology and Mutagenesis0208 environmental biotechnology02 engineering and technology010501 environmental sciencesMucin 5ACBROMINATED FLAME RETARDANTSmedicine.disease_cause01 natural sciencesPolybrominated diphenyl ethersPARTICULATE MATTERElectric ImpedanceHalogenated Diphenyl EthersFlame RetardantsInhalationTight junctionAIRWAY MUCUSChemistryGeneral Medicinerespiratory systemPollutionMucin-5BINTRACELLULAR GLUTATHIONEPolybrominated diphenyl ethers; Inflammation; Oxidative stress; Mucins; Epithelial barrier integrity; Rheological propertiesmedicine.anatomical_structureNADPH Oxidase 4medicine.symptomEnvironmental EngineeringInflammationBronchiEXPOSURE SYSTEMTight JunctionsAndrologymedicineEnvironmental ChemistryHumansRheological propertiesPolybrominated diphenyl ether0105 earth and related environmental sciencesAgedInflammationEpithelial barrier integrityPOLYBROMINATED DIPHENYL ETHERSMucinInterleukin-8MucinsPublic Health Environmental and Occupational HealthEpithelial CellsGeneral ChemistryN-ACETYLCYSTEINEEpithelium020801 environmental engineeringrespiratory tract diseasesOxidative StressA549 CellsMucinEX-VIVO MODELOxidative streRespiratory epitheliumAEROSOL-PARTICLESOxidative stressChemosphere
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Light Scattering as an Easy Tool to Measure Vesicles Weight Concentration

2020

Over the last few decades, liposomes have emerged as promising drug delivery systems and effective membrane models for studying biophysical and biological processes. For all applications, knowing their concentration after preparation is crucial. Thus, the development of methods for easily controlling vesicles concentration would be of great utility. A new assay is presented here, based on a suitable analysis of light scattering intensity from liposome dispersions. The method, tested for extrusion preparations, is precise, easy, fast, non-destructive and uses a tiny amount of sample. Furthermore, the scattering intensity can be measured indifferently at different angles, or even by using the…

Materials scienceStewart assay; extrusion; light scattering; spectrofluorimeter; vesicles; weight concentration.Stewart assayMicrofluidicsFiltration and Separation02 engineering and technologylcsh:Chemical technologyHomogenization (chemistry)ArticleLight scattering03 medical and health sciencesChemical Engineering (miscellaneous)lcsh:TP1-1185Vesicleslcsh:Chemical engineeringWeight concentration030304 developmental biologySpectrofluorimeter0303 health sciencesExtrusionScatteringProcess Chemistry and TechnologyVesiclelight scattering liposomes concentrationlcsh:TP155-156Light scattering021001 nanoscience & nanotechnologyMembraneSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoExtrusion0210 nano-technologyBiological systemMass fractionMembranes
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