0000000000606501

AUTHOR

Paolo Vescovi

showing 27 related works from this author

Type of surgical treatment and recurrence of oral leukoplakia: A retrospective clinical study

2017

Background: Oral leukoplakia (OL) is the most typical potentially malignant disorder of the oral mucosa. We aimed to evaluate the clinical outcome of oral leukoplakia treated with several types of lasers and with the use of quantic molecular resonance (QMR) lancet, in terms of recurrence rate. Material and Methods: Eighty-seven previously untreated OL (52 occurring in females and 35 in males, mean age of 59.4 ± 13.9 years) were consecutively submitted to surgical treatment at University Hospital of Parma, Italy, and Hospital de Valongo, Portugal, (1999 to 2012). Interventions were subclassified into 5 groups according to the instrument used for the surgical removal of OL (cold blade – 17; N…

AdultMalemedicine.medical_specialtyOral Surgical ProceduresRetrospective data03 medical and health sciences0302 clinical medicineRecurrencemedicineHumansOral mucosaSurgical treatmentGeneral DentistryUNESCO:CIENCIAS MÉDICASLeukoplakiaAgedRetrospective StudiesAged 80 and overUnivariate analysisOral Medicine and Pathologybusiness.industryResearchRetrospective cohort study030206 dentistryMiddle Agedmedicine.diseaseUniversity hospitalSurgeryOral leukoplakiamedicine.anatomical_structureOtorhinolaryngology030220 oncology & carcinogenesisSurgeryFemaleLaser TherapyLeukoplakia OralbusinessMedicina Oral, Patología Oral y Cirugía Bucal
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Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

Part iiimedicine.medical_specialtyRound tablebusiness.industryPhysiologyGeneral surgeryPhysiology (medical)Oral and maxillofacial pathologymedicineItalian Consensus Medication-Related OsteoNecrosis of Jaws MRONJmedicine.diseasebusiness
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Salivary biomarkers for diagnosis of systemic diseases and malignant tumors. A systematic review

2019

Background Saliva evaluation could be a possible alternative to blood and/or tissue analyses, for researching specific molecules associated to the presence of systemic diseases and malignancies. The present systematic review has been designed in order to answer to the question “are there significant associations between specific salivary biomarkers and diagnosis of systemic diseases or malignancies?”. Material and Methods The Preferred Reporting Item for Systematic Reviews and Meta-analysis (PRISMA) statement was used to guide the review. The combinations of “saliva” and “systemic diseases” or “diagnosis” or “biomarkers” or “cancers” or “carcinoma” or “tumors”, were used to search Medline, …

medicine.medical_specialtyMEDLINEReviewDisease03 medical and health sciences0302 clinical medicineNeoplasmsInternal medicineCarcinomamedicineHumansSalivaLung cancerGeneral DentistryOral Medicine and Pathologybusiness.industry030206 dentistryEvidence-based medicinemedicine.disease:CIENCIAS MÉDICAS [UNESCO]Systematic reviewOtorhinolaryngologyCardiovascular DiseasesMeta-analysisInclusion and exclusion criteriaUNESCO::CIENCIAS MÉDICASSurgerybusinessBiomarkers
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Low energy KTP laser in oral soft tissue surgery: A 52 patients clinical study

2011

Objectives: Since 1962 laser appliances have been used for soft tissues surgery of oral cavity with significant advantages compared to the traditional instruments: excellent bleeding control, possibility to avoid the use of suture, good patient compliance thanks to a decrease of intra- and post-operative discomfort and biostimulating effect. Unfortunately, the wavelengths so far used have been seen to cause, in association with an excellent ablation capacity, heat damage of the tissues that can decrease healing process and cause a greater discomfort to patients. The aim of this study was to evaluate the laser-assisted KTP laser surgery at low power in terms of characteristics of interventio…

Malemedicine.medical_specialtyOral surgerymedicine.medical_treatmentOral Surgical ProceduresLasers Solid-Statelaw.inventionClinical studyOral soft tissuesYoung AdultLow energylawmedicineHumansGeneral DentistryMouthbusiness.industrySoft tissue:CIENCIAS MÉDICAS [UNESCO]AblationLaserSurgeryOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASKtp laserResearch-ArticleLaser in DentistryFemaleSurgerybusinessMedicina Oral Patología Oral y Cirugia Bucal
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Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Ora…

2021

Background: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results: Oral lichen planus pati…

OralSleep Wake DisordersCancer Researchmedicine.medical_specialtyanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbance; Anxiety; Case-Control Studies; Depression; Female; Humans; Pathology Oral; Reproducibility of Results; Sleep; Surveys and Questionnaires; Lichen Planus Oral; Sleep Wake DisordersinsomniaReproducibility of Resultoral lichen planuPathology and Forensic MedicineSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHEPittsburgh Sleep Quality Indexoral lichen planusstomatognathic systemSurveys and QuestionnairesInsomniamedicineNumeric Rating ScalePathologySurveys and QuestionnaireHumansanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbancemood disturbanceSleep disorderbusiness.industryDepressionEpworth Sleepiness ScaleLichen PlanusReproducibility of ResultsRating scales for depressionmedicine.diseaseanxietysleep disturbancehumanitiesstomatognathic diseasesOtorhinolaryngologyCase-Control StudiesPathology OralPhysical therapyPeriodonticsAnxietyOral lichen planusFemaleOral Surgerymedicine.symptomCase-Control StudiebusinessSleepHumanLichen Planus Oral
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Oral postinflammatory pigmentation : an analysis of 7 cases

2010

Oral postinflammatory pigmentation (OPP) is a discoloration of the oral mucosa caused by an excess of melanin production and deposition within the basal layer of the epithelium and connective tissue of areas affected by chronic inflammation. Therefore, it is mandatory to demonstrate the association with a previous or concomitant inflammatory process in the same area of oral mucosa. Clinically OPP appears as a localized or diffuse, black to brown pigmentation. OPP may persist for many years even though the disappearing of the pigmentation after the resolution of the inflammatory state has been reported. We reviewed retrospectively the medical records and, when performed, biopsy examinations …

AdultMalePathologymedicine.medical_specialtyConnective tissueMelaninBasal (phylogenetics)BiopsymedicineHumansOral mucosaGeneral DentistryAgedRetrospective StudiesHypopigmentationStomatitisHigh prevalencemedicine.diagnostic_testbusiness.industryMouth MucosaMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]stomatognathic diseasesmedicine.anatomical_structureOtorhinolaryngologyConcomitantUNESCO::CIENCIAS MÉDICASFemaleSurgeryOral lichen planusbusiness
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Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

On 20 October 2018 a Closed Round Table brought together a wide range of stakeholders from several medical disciplines, including academic experts, dentists, oncologists, maxillo-facial surgeons, oral surgeons, radiologists, under the technical and scientific coordination of Giuseppina Campisi (for SIPMO) and Giacomo Oteri (for Italian Society of Oral Surgery- SIdCO).

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchinePhysiologySettore MED/28 - Malattie OdontostomatologichePhysiology (medical)italian consensus mroj
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Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the S…

2022

Abstract Background Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. Methods 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality In…

OralCross-Sectional StudieLichen PlanusItaly; Oral lichen planus; Pain; Psychological profile; Sleep disturbancesSleep disturbancePainSleep disturbancesAnxietySettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHECross-Sectional StudiesOral lichen planuItalyPsychological profileItaly; Oral lichen planus; Pain; Psychological profile; Sleep disturbances; Anxiety; Cross-Sectional Studies; Humans; Pain; Pathology Oral; Lichen Planus OralOral lichen planusPathologyPathology OralHumansGeneral DentistryHumanLichen Planus Oral
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Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retro…

2012

Abstract PURPOSE: The aim of this study was to evaluate the results of the surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a large cohort. MATERIALS AND METHODS: A retrospective cohort multicenter study was designed. Patients were enrolled if they were diagnosed with BRONJ and received operative treatment. Data on demographic, health status, perioperative, and surgical factors were collected retrospectively. The primary outcome variable was a change in BRONJ staging (improvement, worsening, or no change). Interventions were grouped by local debridement and resective surgery. Data were collected for other variables as cofactors. Univariate analysis and logist…

AdultMalemedicine.medical_specialtyMultivariate analysismedicine.medical_treatmentLogistic regressionSettore MED/28 - Malattie OdontostomatologicheHumansMedicinebisphosphonate-related osteonecrosis of the jawsAgedRetrospective StudiesAnalysis of VarianceUnivariate analysisChi-Square Distributionbusiness.industryRetrospective cohort studyPerioperativeMiddle AgedBisphosphonatemedicine.diseaseOsteotomySurgeryTreatment OutcomeDebridementItalyOtorhinolaryngologySurgical Procedures OperativeTooth ExtractionRegression AnalysisBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgeryOral SurgerybusinessOsteonecrosis of the jawChi-squared distribution
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Non-invasive visual tools for diagnosis of oral cancer and dysplasia: a systematic review

2016

Background: Gold standard for the diagnosis of oral dysplasia (OD) oral squamous cell carcinoma (OSCC) and malignant lesions is the histological examination. Several adjunctive diagnostic techniques have been proposed in order to increase the sensitivity (SE) and specificity (SP) of conventional oral examination and to improve the diagnostic first level accuracy. The aim of this study is to perform a systematic review on non-invasive tools for diagnosis of OD and early OSCC. Material and Methods: Medline, Scopus, Web of Knowledge databases were searched, using as entry terms “oral dysplasia AND diagnosis” / ”oral cancer AND diagnosis”. Data extracted from each study included number of lesio…

Pathologymedicine.medical_specialtyMEDLINEOdontologíaReviewSensitivity and Specificity03 medical and health sciences0302 clinical medicinePositive predicative valueCarcinomamedicineHumansTolonium ChlorideGeneral DentistryOral DysplasiaOral Medicine and PathologyHyperplasiabusiness.industryCancer030206 dentistryGold standard (test)medicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludClinical trialstomatognathic diseasesOtorhinolaryngologyDysplasia030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellSurgeryMouth NeoplasmsRadiologybusiness
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Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

2020

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SI…

bisphosphonateOral SurgeonHealth Toxicology and Mutagenesislcsh:MedicineMRONJantiangiogenic agents; antiresorptive drugs; bisphosphonates; cancer; denosumab; dentistry; MRONJ; oral surgery; osteoporosis; prevention models; bisphosphonate-associated osteonecrosis of the jaw; bone density conservation agents; diphosphonates; humans; Italy; quality of life0302 clinical medicineprevention modelCancerantiangiogenic agentsdentistryBone Density Conservation AgentsDiphosphonatesConference ReportBisphosphonatesAntiresorptive DrugsDenosumabItaly030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawDenosumabmedicine.drugoral surgerymedicine.medical_specialtyOral surgery03 medical and health sciencesOral surgeryAntiangiogenic agentsOral and maxillofacial pathologymedicinecancerHumansantiangiogenic agentantiresorptive drugsIntensive care medicinePrevention modelsbisphosphonatesantiresorptive drugAntiangiogenic agentsbusiness.industrylcsh:RPublic Health Environmental and Occupational Healthdenosumab030206 dentistrymedicine.diseaseosteoporosisAntiresorptive drugsDentistryOsteoporosisprevention modelsbusinessAntiangiogenic agents; Antiresorptive drugs; Bisphosphonates; Cancer; Denosumab; Dentistry; MRONJ; Oral surgery; Osteoporosis; Prevention models
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Case series of 589 tooth extractions in patients under bisphosphonates therapy. Proposal of a clinical protocol supported by Nd: YAG low-level laser …

2013

Objective: Trauma during dental surgery is a predisposing factor for bisphosphonates (BP)-related osteonecrosis of the jaws (BRONJ). However, about 40% of cases of BRONJ are not related to dental invasive procedures, being probably associated to endodontic or periodontal infections. Extraction of non-treatable teeth is considered a reliable choice, to improve symptoms and to reduce the risk of BRONJ. Here we report our experience of tooth extractions in patients under oral or intravenous BP therapy. Study Design: Two-hundred and seventeen patients (38 males, 179 females; mean age 68.72 ± 11.26 years, range 30 to 83 years) under BP therapy received 589 tooth extractions at the Unit of Oral M…

AdultMalemedicine.medical_specialtymedicine.drug_classmedicine.medical_treatmentOsteoporosisAntibioticsDentistryOdontologíaLasers Solid-StatePostoperative ComplicationsClinical ProtocolsmedicineHumansLow-Level Light TherapyDental CareGeneral DentistryMultiple myelomaLow level laser therapyAgedAged 80 and overBisphosphonate-associated osteonecrosis of the jawDiphosphonatesbusiness.industryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludSurgerystomatognathic diseasesOtorhinolaryngologyRheumatoid arthritisDental surgeryTooth ExtractionUNESCO::CIENCIAS MÉDICASResearch-ArticleBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgeryOral SurgerybusinessOral medicine
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Psychological profile and unexpected pain in oral lichen planus: a case-control multicenter SIPMO study

2021

Objectives: To analyze psychological profiles, pain and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes) and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered. Results: Th…

medicine.medical_specialtyoral lichen planuPittsburgh Sleep Quality IndexSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE03 medical and health sciences0302 clinical medicineoral lichen planusstomatognathic systemmental disordersmedicineanxiety; depression; oral lichen planus; pain; sleep disturbancepainGeneral DentistrySleep disorderbusiness.industryEpworth Sleepiness ScaleRating scales for depression030206 dentistrymedicine.diseaseanxietysleep disturbanceDermatologyhumanitiesstomatognathic diseasesPeripheral neuropathyOtorhinolaryngologyMood disorders030220 oncology & carcinogenesisdepressionAnxietyOral lichen planusmedicine.symptombusiness
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Conservative Surgical Management of Stage I Bisphosphonate-Related Osteonecrosis of the Jaw

2014

Purpose. To report the efficacy of conservative surgical treatment for stage I bisphosphonate-related osteonecrosis of the jaw (BRONJ).Materials and Methods. This study reports the clinical outcomes of 63 patients treated for BRONJ stage I (according to Ruggiero's staging system) at the Oral Pathology and Laser-Assisted Surgery Unit of the University of Parma between January 2004 and January 2011. Surgical interventions were performed, under local analgesia, in patients unresponsive for a period of six months to noninvasive treatments such as cycles of local or systemic antibacterial therapy combined or not to low level laser therapy, ozone therapy, or Hyperbaric Oxygen Therapy. All interve…

medicine.medical_specialtyArticle Subjectbusiness.industrymedicine.medical_treatmentDiseaseBisphosphonatemedicine.diseaseOzone therapySurgerylcsh:RK1-715lcsh:DentistryOral and maxillofacial pathologymedicineClinical StudyIn patientbusinessOsteonecrosis of the jawGeneral DentistryStaging systemLow level laser therapyInternational Journal of Dentistry
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Osteonecrosis of the jaw (ONJ) risk in breast cancer patients after zoledronic acid treatment

2010

The importance of adoption of recommendations for ONJ prevention strategy will notably grow for zoledronic acid in the next future, in view of possible further enlargement of its indications (even with different timing and schedules) in breast cancer patients without bone metastases (such as in adjuvant and neo-adjuvant settings, and in hormonotherapy-induced osteopenia

Oncologymedicine.medical_specialtyBreast Neoplasmszoledronic acidBreast cancerSettore MED/28 - Malattie OdontostomatologicheInternal medicinemedicineHumansBone Density Conservation AgentsDiphosphonatesOsteonecrosis of the jawbusiness.industryImidazolesOsteonecrosisGeneral Medicinemedicine.diseaseosteonecrosis jawsZoledronic acidJawbreast cancer patientsFemaleSurgerybusinessOsteonecrosis of the jawmedicine.drugThe Breast
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Odontogenic myxofibroma: a concise review of the literature with emphasis on the surgical approach

2014

Purpose: The aim of this work is to report a review of the literature concerning epidemiology, clinical and radiographic features as well as treatment of odontogenic myxofibroma (MF). Methods: The PubMed database was searched using the following keywords: “odontogenic myxofibroma”, “odontogenic fibromyxoma”, “myxofibroma of the jaw” and “fibromyxoma of the jaw”. Results: Fifteen articles reporting the experience with 24 patients were identified. Male/female ratio was 1:1.4 and the average age was 29.5 years. The most frequent location was the mandible. In 66.7% of the cases the radiographic appearance was a multilocular radiolucency. Swelling was observed in 13 patients (92.86%), varying de…

AdultMalemedicine.medical_specialtyRadiographyMEDLINEOdontogenic TumorsOdontologíaFibromaReviewEpidemiologymedicineHumansRadical surgeryGeneral DentistryOdontogenic MyxofibromaOral Medicine and PathologySurgical approachbusiness.industryMandiblemedicine.disease:CIENCIAS MÉDICAS [UNESCO]Jaw NeoplasmsCiencias de la saludSurgeryOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASFemaleSurgeryRadiologyFibromabusiness
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Nonexposed Variant of Bisphosphonate-associated Osteonecrosis of the Jaw: A Case Series

2010

Abstract Purpose To report a case series of patients with the nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw—a form of jaw osteonecrosis that does not manifest with necrotic bone exposure/mucosal fenestration. Methods Among 332 individuals referred to 5 clinical centers in Europe because of development of jawbone abnormalities after or during exposure to bisphosphonates, we identified a total of 96 patients who presented with the nonexposed variant of osteonecrosis. Relevant data were obtained via clinical notes; radiological investigations; patients' history, and referral letters. Results The most common clinical feature of nonexposed osteonecrosis was jaw bone pa…

OsteochemonecrosisMaleTime FactorsAvascular necrosisMandibleAvascular necrosiEpidemiologyMaxillaProspective cohort studyMultiple myelomaAged 80 and overeducation.field_of_studyAlendronateBone Density Conservation AgentsDiphosphonatesOsteochemonecrosiOsteonecrosisGeneral MedicineBisphosphonatesMiddle AgedKidney NeoplasmsEuropeAvascular necrosisFemaleMultiple MyelomaAdultmedicine.medical_specialtyPopulationJawsBreast NeoplasmsSettore MED/28 - Malattie OdontostomatologicheJawbonesmedicineHumansBisphosphonateeducationAgedBisphosphonate-associated osteonecrosis of the jawbusiness.industryProstatic NeoplasmsAvascular necrosis; Bisphosphonates; Jawbones; Jaws; Mandible; Maxilla; Osteochemonecrosis; Osteonecrosismedicine.diseaseDermatologySurgeryJawMaxillaOsteoporosisJawbonebusinessOsteonecrosis of the jawJaw Diseases
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Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

On 20 October 2018 a Closed Round Table brought together a wide range of stakeholders from several medical disciplines, including academic experts, dentists, oncologists, maxillo-facial surgeons, oral surgeons, radiologists, under the technical and scientific coordination of Giuseppina Campisi (for SIPMO) and Giacomo Oteri (for Italian Society of Oral Surgery- SIdCO)

SIPMOBRONJ (bisphosphonate-related osteonecrosis of the jaw)Risk of inappropriatenessSIdCOPhysiologyPhysiology (medical)Italian consensus mrojMRONJ Italian ConsensusMRONJONJ (osteonecrosis of the jaws)BRONJ (bisphosphonate-related osteonecrosis of the jaw)Risk of inappropriatenessMRONJ Italian ConsensusSIPMOSIdCOMRONJONJ (osteonecrosis of the jaws)
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Surgery-triggered and non surgery-triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): A retrospective analysis of 567 cases in an Ita…

2011

Invasive local procedures are often reported in clinical history of patients suffering from Bisphosphonates-Related Osteonecrosis of the Jaws (BRONJ) but over 40% of spontaneous forms have been also described in literature. We compared age, gender, underlying bone disorders, bisphosphonate therapy, clinical features and surgical outcome of 205 cases (36.2%) of BRONJ non surgery-triggered (group 1) with 362 (63.8%) cases of surgery-triggered forms (group 2). Differences between group 1 and 2 were analysed using Mann-Whitney U and χ2 tests. Statistical analysis was performed using STATA 8. Zoledronate was the most used type of bisphosphonate (63.4% versus 69.0%) and the mandible was the most …

AdultMaleCancer Researchmedicine.medical_specialtyTooth extractionmedicine.medical_treatmentZoledronic AcidSettore MED/28 - Malattie OdontostomatologicheRisk FactorsClinical historySpontaneous formmedicineRetrospective analysisHumansStatistical analysisStage (cooking)AgedRetrospective StudiesAged 80 and overSurgical outcomeBone Density Conservation AgentsDiphosphonatesBRONJOrthognathic Surgical Proceduresbusiness.industryImidazolesOsteonecrosisBisphosphonates-related Osteonecrosis of the JawMiddle AgedBisphosphonateSurgeryZoledronic acidItalyOncologyMulticenter studyFemaleBisphosphonate therapyOral SurgerybusinessJaw Diseasesmedicine.drugOral Oncology
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Osteonecrosis of the Jaw in Patients With Metastatic Renal Cell Cancer Treated With Bisphosphonates and Targeted Agents: Results of an Italian Multic…

2015

Osteonecrosis of the jaw (ONJ) associated with the use of bisphosphonates has been rarely reported in metastatic renal cell cancer (RCC) patients. Since the introduction of combined therapies consisting of nitrogen-containing bisphosphonates (NBPs) and targeted agents, an increasing number of RCC patients were reported to develop ONJ, suggesting that therapeutic angiogenesis suppression might increase the risk of ONJ in NBPs users. We performed a multicenter retrospective study and reviewed literature data to assess the occurrence and to investigate the nature of ONJ in RCC patients taking NBPs and targeted agents. Nine Italian Centers contributed to the data collection. Patients with expos…

MaleOncologyIndolesAngiogenesis InhibitorsPyrroleBevacizumab; m-TOR inhibitor; Sorafenib; Sunitinib; Zoledronic acidRetrospective StudieAntineoplastic Combined Chemotherapy ProtocolsSunitinibAged 80 and overDiphosphonatesSunitinibImidazolesOsteonecrosisKidney NeoplasmMiddle AgedSorafenibKidney NeoplasmsBevacizumabDiphosphonateItalyOncologyOsteonecrosiFemaleAngiogenesis InhibitorHumanmedicine.drugSorafenibmedicine.medical_specialtyBevacizumab; m-TOR inhibitor; Sorafenib; Sunitinib; Zoledronic acid; Aged; Aged 80 and over; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Carcinoma Renal Cell; Diphosphonates; Female; Humans; Imidazoles; Indoles; Italy; Jaw; Kidney Neoplasms; Male; Middle Aged; Osteonecrosis; Pyrroles; Retrospective Studies; Oncology; UrologyBevacizumabUrologyInternal medicinemedicineHumansPyrrolesIn patientMetastatic renal cell cancerImidazoleCarcinoma Renal CellZoledronic acidAgedRetrospective StudiesAntineoplastic Combined Chemotherapy Protocolbusiness.industryRetrospective cohort studymedicine.diseasem-TOR inhibitorSurgeryZoledronic acidJawIndolebusinessOsteonecrosis of the jaw
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Thermal increase in the oral mucosa and in the jawbone during Nd:YAG laser applications. Ex vivo study

2012

Objective: Literature reports bactericidal and biostimulant effects for Nd:YAG laser procedures on bone and oral mucosa but the possible overheating can cause damage to anatomical structures. The aim of the study is the evaluation of thermal increase in different levels of oral tissues: mucosa, periosteum and bone during defocused application of Nd:YAG laser at different parameters. Study Design: Superficial thermal evaluation was performed in pig jaws with a thermal camera device; deep thermal evaluation was realized by 4 thermocouples placed at a subperiosteal level and at 1,2 and 4 mm depth in the jaw bone. Laser applications of 1 minute were performed 5 times (with a pause of 1 minute) …

medicine.medical_specialtyMaterials scienceHot TemperatureSwinemedicine.medical_treatmentLasers Solid-StateIn Vitro Techniqueslaw.inventionBody TemperatureThermocouplelawClinical and Experimental DentistryThermalmedicineAnimalsOral mucosaGeneral DentistryRest timeLow level laser therapyMouth Mucosa:CIENCIAS MÉDICAS [UNESCO]LaserSurgerymedicine.anatomical_structureOtorhinolaryngologyJawNd:YAG laserUNESCO::CIENCIAS MÉDICASSurgeryResearch-ArticleThermal relaxationBiomedical engineeringMedicina Oral, Patología Oral y Cirugía Bucal
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Clinical Validation of 13-gene DNA Methylation Analysis from Oral Brushing: A Non Invasive Sampling Procedure for Early Detection of Oral Squamous Ce…

2019

In a recent study our research group described a non-invasive sampling procedure based on [...]

Oncologymedicine.medical_specialtyoral brushing;oral squamous cell carcinoma; quantitative DNA methylation analysisbusiness.industryEarly detectionSampling (statistics)oral brushingoral squamous cell carcinomaInternal medicineDNA methylationMedicinequantitative DNA methylation analysisBasal cellGene DNA Methylation Analysis Oral Brushing Non Invasive Sampling Early Detection Oral Squamous Cell CarcinomabusinessNon invasive samplingGeneThe XV National and III International Congress of the Italian Society of Oral Pathology and Medicine
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A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid…

2017

Background The aim of this study was to evaluate the incidence and the risk factors of osteonecrosis of the jaw (ONJ) in a group of patients treated with zoledronic acid (ZA) for bone metastases from solid tumors and enrolled in a preventive dental program. Material and Methods This 5-year retrospective longitudinal study included all consecutive oncological patients who underwent at least one infusion with ZA between 2004 and 2011 for bone metastases due to solid neoplasms. Results Of the 156 patients enrolled in the study, 17 developed ONJ (10.89%). At the multivariate analysis, severe periodontal disease (P=0.025), tooth extraction (P<0.0001) and starting the preventive dental program af…

Malemedicine.medical_specialtyLongitudinal studyTime FactorsBone NeoplasmsZoledronic Acid03 medical and health sciences0302 clinical medicinestomatognathic systemRisk FactorsmedicineHumansIn patientLongitudinal StudiesGeneral DentistryAgedRetrospective StudiesBisphosphonate-associated osteonecrosis of the jawBone Density Conservation AgentsDiphosphonatesbusiness.industryIncidence (epidemiology)ResearchIncidenceImidazolesRetrospective cohort study030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseMedically compromised patients in DentistrySurgeryBone Density Conservation Agentsstomatognathic diseasesZoledronic acidOtorhinolaryngology030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASSurgeryBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawbusinessmedicine.drugMedicina oral, patologia oral y cirugia bucal
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Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

2013

Abstract Background Bisphosphonates (BPs) are currently the chief drugs for the prevention/treatment of osteoporosis; one of their adverse effects is the osteonecrosis of the jaw (BRONJ). The primary endpoints of this multi-center cross-sectional study are: i) an observation of the clinical features of BRONJ in 87 osteoporotic, non-cancer patients; and ii) an evaluation of their demographic variables and comorbidities. Methods 87 BRONJ patients in therapy for osteoporosis with BPs from 8 participating clinical Italian centers were consecutively identified and studied. After BRONJ diagnosis and staging, comorbidities and data relating to local and drug-related risk factors for BRONJ were col…

medicine.medical_specialtyTime FactorsMultivariate analysisHeart DiseasesOsteoporosisSettore MED/50 - Scienze Tecniche Mediche ApplicateAdministration OralMandibleOsteonecrosis jawHospital based studyAdrenal Cortex HormonesRisk FactorsSettore MED/28 - Malattie OdontostomatologicheInternal medicineDiabetes MellitusInternal MedicinemedicineHumansIn patientRisk factorOral bisphopshonateAdverse effectOsteoporosis PostmenopausalAgedRetrospective StudiesAged 80 and overAlendronateBone Density Conservation AgentsDiphosphonatesbusiness.industryLiver DiseasesIncidence (epidemiology)Age FactorsMiddle Agedmedicine.diseaseSurgeryCross-Sectional StudiesItalyOral bisphopshonates; Osteonecrosis jaws; OsteoporosisHypertensionMultivariate AnalysisOsteoporosisBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawbusiness
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Large-sized pleomorphic adenoma of the cheek treated with Nd:Yag laser: Report of a case and review of the literature

2020

Pleomorphic adenoma (PA) mostly involves parotid glands, while extra-parotid localizations are relatively uncommon. Particularly, PAs of the cheek minor salivary glands with a size larger than 4 cm are exceedingly rare, with only few cases reported. Surgical treatment of PA usually consists in radical excision. However, despite a presumptive radicality, recurrences, sometimes followed by malignant transformation, may occur. Here we report a case of a large-sized (6 cm) PA of the cheek minor salivary glands in a 70 year-old female patient, successfully treated through a conservative approach, based on the use of Nd:YAG Laser (λ=1064 nm). No recurrences were observed after a 2-year follow-up.…

Laser surgerymedicine.medical_specialtyLaser surgerymedicine.medical_treatmentOral pathologyCase ReportPleomorphic adenoma03 medical and health sciences0302 clinical medicineOral surgerystomatognathic systemPleomorphic adenomaOral and maxillofacial pathologyFemale patientmedicineGeneral DentistryMinor salivary glandsMinor Salivary Glandsbusiness.industrySalivary glands tumorsLaser treatment030206 dentistryCheekmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Laser surgery; Minor salivary glands; Oral pathology; Oral surgery; Pleomorphic adenoma; Salivary glands tumorsmedicine.anatomical_structureNd:YAG laserUNESCO::CIENCIAS MÉDICASRadiologybusiness030217 neurology & neurosurgery
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Clinical validation of 13-gene DNA methylation analysis in oral brushing samples for detection of oral carcinoma: an Italian multicenter study

2021

Background The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13-gene DNA methylation analysis in oral brushing samples. Methods Oral brushing specimens were collected in 11 oral medicine centers across Italy. Twenty brushing specimens were collected by each center, 10 from patients with OSCC, and 10 from healthy volunteers. DNA methylation analysis was performed in blindness, and each sample was determined as positive or negative based on a predefined cutoff value. Results DNA amplification failed in 4 of 220 (1.8%) samples. Of the specimens derived from patien…

0301 basic medicinemedicine.medical_specialtyBisulfite sequencingalgorithm; bisulfite sequencing; diagnostic test; oral brushing; oral squamous cell carcinoma; quantitative DNA methylation analysisGastroenterologyoral brushing03 medical and health sciences0302 clinical medicineInternal medicineHealthy volunteersCarcinomamedicineHumansquantitative DNA methylation analysisMouth neoplasmalgorithmbusiness.industryDNA Methylationmedicine.diseaseDna amplificationoral squamous cell carcinomastomatognathic diseases030104 developmental biologyItalyOtorhinolaryngologyMulticenter studyHead and Neck Neoplasmsdiagnostic test030220 oncology & carcinogenesisDNA methylationCarcinoma Squamous Cellbisulfite sequencingMouth NeoplasmsbusinessOral medicine
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Effects of zoledronic acid and dexamethasone on early phases of socket healing after tooth extraction in rats : a preliminary macroscopic and microsc…

2018

Background The exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is still unknown. The aim of this paper was to investigate the effects of zoledronic acid and dexamethasone on the early phases of socket healing in rats subjected to tooth extractions. Material and Methods Thirty male Sprague-Dawley rats were divided into 2 groups: pharmacologically treated group (T, n=20) and non-pharmacologically treated group (C, n=10). T group rats received 0.1 mg/Kg of zoledronic acid (ZOL) and 1 mg/Kg of dexamethasone (DEX) three times a week for 10 consecutive weeks. C group rats were infused with vehicle. After 9 weeks from the first infusion, first maxillary molars were extrac…

MolarMalemedicine.medical_specialtyConnective tissueZoledronic AcidDexamethasoneBone remodelingRats Sprague-Dawley03 medical and health sciences0302 clinical medicineOsteoclastInternal medicinemedicineAnimalsHumansTooth SocketGeneral DentistryDexamethasoneDental alveolusOral Medicine and PathologyBone Density Conservation AgentsDiphosphonatesbusiness.industryResearchOsteonecrosis030206 dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ratsmedicine.anatomical_structureZoledronic acidEndocrinologyOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASTooth ExtractionSurgerybusinessOsteonecrosis of the jawmedicine.drug
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