Cardiac progenitor cells and the development of the human heart

Personality profiles of dyslexic children: a study with the Big Five Questionnaire

Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism

BackgroundWhether the oral factor Xa inhibitor edoxaban can be an alternative to warfarin in patients with venous thromboembolism is unclear. MethodsIn a randomized, double-blind, noninferiority study, we randomly assigned patients with acute venous thromboembolism, who had initially received heparin, to receive edoxaban at a dose of 60 mg once daily, or 30 mg once daily (e.g., in the case of patients with creatinine clearance of 30 to 50 ml per minute or a body weight below 60 kg), or to receive warfarin. Patients received the study drug for 3 to 12 months. The primary efficacy outcome was recurrent symptomatic venous thromboembolism. The principal safety outcome was major or clinically re…

IDENTIFICATION OF C-KIT/CD105 AND ISL-1 CELLS IN HUMAN FETAL AND INFANT HEARTS

During embryogenesis, the mammalian heart develops from a primitive heart tube, which derives from two bilateral primary heart fields located in the lateral plate mesoderm. Later on in the development process, the atrioventricular (A-V) canal and the sinu-atrial segment, at the venous pole, and the conotruncus, at the arterial pole, are added to the heart tube just prior to tube looping. In 2001 Waldo and colleagues and Kelly and colleagues demonstrated the presence of a secondary or anterior heart field in the ventral pharyngeal mesoderm. This region contains a pool of NKX2.5 and GATA-4 positive precardiac cells which migrate to the arterial pole of the primary heart tube. Isl-1 is a marke…