Gastroenterite Eosinofila ed asa triad.

Favara. Servizi ricreativi a nord del centro storico.

Effect of cadmium and manganese on gene expression and “in vitro” proliferative and invasive behaviour of MDA-MB231 human breast cancer cells

The effect of the HDACi JAHA on DNA methylation of breast cancer cells by down-regulating DNMT1 through ERK signaling

Breast cancer cell growth/motility is influenced by metal compounds

Triple-negative breast cancer (TNBC) is a highly "aggressive" malignant neoplasm with limited treatment options due to the lack of expression of estrogen and progesterone receptors and HER2/neu. In search of novel molecules displaying anti-TNBC activities, the TNBC cell line MDA-MB231 was exposed to cadmium chloride and/or manganese chloride, and a biological characterization of the effect observed was performed. The data obtained demonstrate a cytotoxic effect exerted by cadmium chloride with drastic changes affecting gene expressions and production of reactive oxygen species. Conversely, manganese chloride was effective in increasing cell number and promoting cell invasive ability. Such e…