The Sources of Ca2+ for Muscarinic Receptor-induced Contraction in the Rat Ileum

Abstract The contractile responses obtained by activation of different muscarinic receptor subtypes in the longitudinal muscle of the rat ileum and especially the responses of this muscle to acetylcholine in a Ca2+-free medium have been investigated. In Ca2+-containing solution, acetylcholine elicited similar concentration-dependent contractile responses in the duodenum, jejunum and ileum strips of the rat intestine. The response to a maximal concentration of the agonist (1 μM) consisted of a rapid phasic response followed by a slower tonic one. Nifedipine completely relaxes or inhibits the sustained response and only partially diminishes the phasic one, which suggests that the phasic contr…

Determinación de parámetros clínico-patológicos y moleculares implicados en la regresión espontánea de neoplasias melanocíticas cutáneas

Antecedentes y Objetivos: existe evidencia acumulada de que tanto el melanoma como los nevus melanocíticos tienen la capacidad de estimular la respuesta inmune. Se ha demostrado que la regresión en el melanoma es 6 veces más frecuente que en otras neoplasias malignas, y aunque la regresión completa de melanomas es un evento excepcional, se ha constatado que la regresión parcial es frecuente, ya que ocurre entre un 10 y un 35% de los mismos. Desde un punto de vista exclusivamente histológico, cuando la regresión es completa, es muy difícil determinar la naturaleza biológica de la lesión previa, y en la mayoría de ocasiones, tan sólo el desarrollo de metástasis en el seguimiento posterior del…

Leishmaniasis mucocutánea labial, las apariencias pueden engañar.

espanolLa leishmaniasis es una infeccion endemica en nuestro medio. Dentro de sus presentaciones, la forma mucocutanea es la menos frecuente. A pesar de ello se ha de tener en cuenta incluso en casos clinicamente sugestivos de patologia tumoral, como el que presentamos. EnglishLeishmaniasis is an endemic disease in the mediterranean region. Although mucocutaneous presentation is not frequent, we should considerate it in the differential diagnosis of tumoral pathology.

Enfermedad de Riga-Fede

Characteristics of mucocutaneous vascular malformations drawn from a decade of a multidisciplinary committee experience.

Vascular malformations (VM) are congenital, benign, and relatively frequent lesions. Scant data have been published about the epidemiology, clinical presentation, and treatment of VM from a dermatologist's perspective. The substantial differences between subtypes, broad range of specialists consulted and confusing nomenclature used over previous years may hamper a correct diagnosis. The main objective of this study is to describe VM epidemiology. As a secondary endpoint we evaluate clinical characteristics, clinical-radiological correlation and treatment approaches. We carried out an observational, descriptive, retrospective study. Cases presented to the multidisciplinary committee of our h…

Type V aplasia cutis congenita in a preterm newborn successfully resolved

Aplasia cutis congenita (ACC) associated with fetus papyraceus is a rare subtype of aplasia cutis categorized as type V in Frieden's classification. It is characterized by stellate lesions in a symmetrical distribution over the trunk and proximal extremities. Conservative treatment is recommended, but there is not a well-defined therapeutic protocol. We report the case of a type V ACC in a preterm male newborn with lesions on the trunk and scalp successfully treated with topical 1% silver sulfadiazine and petrolatum gauze with an excellent evolution. This case associates a severe affectation of the scalp which represents a rare variant of type V ACC.

Pruriginous Lesions in a Young Girl: Answer.