0000000000609212

AUTHOR

Stefania Sut

showing 5 related works from this author

Chemical Characterization and Cytotoxic and Antioxidant Activity Evaluation of the Ethanol Extract from the Bulbs of Pancratium maritimun Collected i…

2023

P. maritimum L., belonging to the Amaryllidaceae family, is a species that grows on beaches and coastal sand dunes mainly on both sides of the Mediterranean Sea and Black Sea, the Middle East, and up to the Caucasus region. It has been largely investigated due to its several interesting biological properties. With the aim of providing new insights into the phytochemistry and pharmacology of this species, the ethanolic extract of the bulbs from a local accession, not previously studied, growing in Sicily (Italy), was investigated. This chemical analysis, performed by mono- and bi-dimensional NMR spectroscopy, as well as LC-DAD-MSn, allowed to identify several alkaloids, three of which were n…

Amaryllidaceae; alkaloids; cytotoxic activity; antioxidant activity; Caco-2 cellsAmaryllidaceaeOrganic Chemistryantioxidant activityPharmaceutical ScienceSettore CHIM/06 - Chimica OrganicaalkaloidAnalytical ChemistryChemistry (miscellaneous)Drug DiscoveryMolecular MedicinePhysical and Theoretical ChemistryCaco-2 cellscytotoxic activityMolecules
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Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family

2018

The Apiaceae family encompasses aromatic plants of economic importance employed in foodstuffs, beverages, perfumery, pharmaceuticals and cosmetics. Apiaceae are rich sources of essential oils because of the wealth of secretory structures (ducts and vittae) they are endowed with. The Apiaceae essential oils are available on an industrial level because of the wide cultivation and disposability of the bulky material from which they are extracted as well as their relatively cheap price. In the fight against protozoal infections, essential oils may represent new therapeutic options. In the present work, we focused on a panel of nine Apiaceae species (Siler montamon, Sison amomum, Echinophora spi…

Human African trypanosomiasiAlkeneApiaceae; BALB/3T3; Essential oils; Human African trypanosomiasis; Trypanosoma brucei; 3T3 Cells; Alkenes; Animals; Apiaceae; Benzyl Compounds; Cyclohexenes; Dioxolanes; Inhibitory Concentration 50; Mice; Monoterpenes; Oils Volatile; Plant Oils; Pyrogallol; Terpenes; Trypanosoma brucei brucei; Trypanosomiasis; Pollution; Public Health Environmental and Occupational Health; Health Toxicology and MutagenesisHealth Toxicology and Mutagenesis[SDV]Life Sciences [q-bio]VolatileMonoterpeneAllylbenzene DerivativesPlant Oil01 natural sciencesCosmeticsEssential oilTerpenechemistry.chemical_compoundMiceTrypanosoma bruceiBALB/3T3media_commonBicyclic Monoterpenes2. Zero hungerbiologyTraditional medicineChemistryBenzyl CompoundsDioxolanesGeneral Medicine3T3 CellsPollutionHealthEssential oilsTerpeneIdentification (biology)Public HealthDioxolaneCyclohexenesmedia_common.quotation_subjectAcyclic MonoterpenesApiaceae; BALB/3T3; Essential oils; Human African trypanosomiasis; Trypanosoma brucei; 3T3 Cells; Alkenes; Animals; Apiaceae; Benzyl Compounds; Cyclohexenes; Dioxolanes; Inhibitory Concentration 50; Limonene; Mice; Monoterpenes; Oils Volatile; Plant Oils; Pyrogallol; Terpenes; Trypanosoma brucei brucei; TrypanosomiasisTrypanosoma brucei bruceiCyclohexane MonoterpenesTrypanosoma bruceiAlkenesPyrogallolInhibitory Concentration 50TrypanosomiasisBenzyl CompoundsCyclohexenesOils VolatileCyclohexeneAnimalsPlant OilsToxicology and Mutagenesis3T3 CellApiaceaeAnimal010405 organic chemistryTerpenesEnvironmental and Occupational HealthHuman African trypanosomiasisPublic Health Environmental and Occupational Healthbiology.organism_classification0104 chemical sciences010404 medicinal & biomolecular chemistryPyrogallolMonoterpenesCymenesBenzyl CompoundOilsLimoneneApiaceae
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Hairy Garlic (Allium subhirsutum) from Sicily (Italy): LC-DAD-MSn Analysis of Secondary Metabolites and In Vitro Biological Properties

2020

Allium subhirsutum, known as hairy garlic, is a bulbous plant widespread in the Mediterranean area and locally used as a food and spice. In the present study, the chemical profile of the ethanolic extracts from bulbs (BE) and aerial parts (APE) were analyzed by HPLC-ESI-MSn, and antioxidant properties were evaluated by DPPH, ABTS and TEAC assays. The traditional use in the diet, and the well documented biological activity of Allium species suggest a potential as a new nutraceutical. For this reason, the potential usefulness of this food can be considered in the treatment and prevention of degenerative Alzheimer disease. For this reason, acetylcholinesterase inhibitory property was investiga…

ethanolic extractsAntioxidantAllium subhirsutumplant extractsDPPHmedicine.medical_treatmentPharmaceutical Scienceantioxidant activity01 natural sciencesAnalytical Chemistrylcsh:QD241-44103 medical and health scienceschemistry.chemical_compoundNutraceuticallcsh:Organic chemistryDrug DiscoverymedicinePhysical and Theoretical Chemistry030304 developmental biology0303 health sciencesABTSTraditional medicinebiologyhairy garlicOrganic ChemistryIn vitro toxicologyfood and beveragesBiological activitybiology.organism_classification0104 chemical sciences010404 medicinal & biomolecular chemistrychemistryChemistry (miscellaneous)Molecular MedicineAlliumcytotoxicityacetylcholinesterase inhibitorMolecules
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High-Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry (HPLC-ESI-MSn) Analysis and Bioactivity Useful for Prevention…

2019

This study aimed at evaluating and comparing the chemical profile obtained by HPLC-ESI-MSn analysis, the inhibitory activity of enzymes linked to obesity (α-amylase, α-glucosidase, and lipase) and the antioxidant properties (DPPH, ABTS, FRAP, and β-carotene bleaching tests) of ethanol extracts of bulbs (BE) and aerial parts (APE) from Allium commutatum Guss. (known in Italy as “aglio delle isole”). The chemical profile revealed alliin as the main abundant compound with values of 31.5 and 38.8 mg/g extract for BE and APE, respectively. APE is rich also in quercetin (38.5 mg/g extract) and luteolin (31.8 mg/g extract). Bulbs extract exhibited the highest activity as inhibitor of enzymes linke…

0301 basic medicineDPPHAllium commutatumElectrospray ionizationBulbsAlliinHigh-performance liquid chromatographyAntioxidantsAllium03 medical and health scienceschemistry.chemical_compound0404 agricultural biotechnologyAntioxidant activityTandem Mass SpectrometryCarbohydrate-hydrolysing enzymes inhibitionEnzyme InhibitorsGarlicChromatography High Pressure Liquid030109 nutrition & dieteticsABTSChromatographybiologyPlant Extracts04 agricultural and veterinary sciencesbiology.organism_classification040401 food scienceLipase inhibitionItalychemistryChemistry (miscellaneous)AlliumAerial parts; Antioxidant activity; Bulbs; Carbohydrate-hydrolysing enzymes inhibition; Garlic; Lipase inhibitionAerial partsQuercetinFood SciencePlant Foods for Human Nutrition
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Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in…

2023

Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main factors sustaining PDAC progression, the alteration of cell metabolism has emerged to have a key role in PDAC cell proliferation, invasion, and resistance to standard chemotherapeutic agents. Taking into account all these factors and the urgency in evaluating novel options to treat PDAC, in the present work we reported the synthesis of a new series of indolyl-7-azaindolyl triazine compounds inspired by marine bis-indolyl alkaloids. We first assessed the ability of the new triazine compounds to inhibit the enzymatic activity of pyruvate de…

nortopsentin analoguespancreatic ductal adenocarcinoma (PDAC); nortopsentin analogues; antitumor activity; pyruvate dehydrogenase kinases (PDKs); cytotoxic activity; metabolic alterations; ligand-based homology modeling; KRASDrug Discoveryligand-based homology modelingKRASPharmaceutical Scienceantitumor activitymetabolic alterationspancreatic ductal adenocarcinoma (PDAC)Pharmacology Toxicology and Pharmaceutics (miscellaneous)cytotoxic activitypyruvate dehydrogenase kinases (PDKs)
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