0000000000614216

AUTHOR

David Belin

showing 2 related works from this author

Chronic exposure to glucocorticoids induces suboptimal decision-making in mice.

2021

AbstractAnxio-depressive symptoms as well as severe cognitive dysfunction including aberrant decision-making (DM) are documented in neuropsychiatric patients with hypercortisolaemia. Yet, the influence of the hypothalamo-pituitary-adrenal (HPA) axis on DM processes remains poorly understood. As a tractable mean to approach this human condition, adult male C57BL/6JRj mice were chronically treated with corticosterone (CORT) prior to behavioural, physiological and neurobiological evaluation. The behavioural data indicate that chronic CORT delays the acquisition of contingencies required to orient responding towards optimal DM performance in a mouse Gambling Task (mGT). Specifically, CORT-treat…

Chronic exposureMaleendocrine systemHypothalamo-Hypophyseal System[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyPituitary-Adrenal SystemSpatial memory03 medical and health scienceschemistry.chemical_compoundGambling taskMice0302 clinical medicineGlucocorticoid receptorCorticosteroneMedicineAnimalsHumansPharmacology (medical)Prefrontal cortexGlucocorticoidsBiological PsychiatryPharmacologybusiness.industry[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyCognition030227 psychiatryMice Inbred C57BLPsychiatry and Mental healthNeurologychemistryNeurology (clinical)Biological psychiatryMotor learningbusinessCorticosteroneNeuroscience030217 neurology & neurosurgeryhormones hormone substitutes and hormone antagonistsStress PsychologicalDecision-making
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The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeki…

2015

Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioi…

Malemedicine.medical_specialtyAlcohol Drinkingmedia_common.quotation_subjectNarcotic AntagonistsDrug-Seeking BehaviorDrug Evaluation PreclinicalReceptors Opioid muPoison controlAlcoholContext (language use)Choice BehaviorNaltrexonechemistry.chemical_compoundSpecies SpecificitymedicineAnimalsPsychiatrymedia_commonPharmacologyDose-Response Relationship DrugAddictionAbstinenceTriazolesNaltrexoneRatsPsychiatry and Mental healthDisease Models AnimalchemistryAlcohol DeterrentsAnesthesiaIndansCommentaryConditioning OperantBlood alcohol contentBlood Alcohol ContentCuesPsychologyAlcohol-Related DisordersReinforcement Psychologymedicine.drugAlcohol DeterrentsNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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