0000000000615022
AUTHOR
Conigliaro
showing 2 related works from this author
A multifuctional nanoplatform for drug targeted delivery based on radiation-engineered nanogels
2020
Abstract Under a rational design, combining biologically active molecules, ligands to specific cell receptors and fluorescent, radioactive or paramagnetic labels into a single nano-object can bridge the unique properties of the individual components and improve conventional sensing, imaging and therapeutic efficacies. The validation of these functional nano-objects requires careful testing both in terms of physico-chemical properties and biological behaviour in vitro and in vivo, prior to translation into the clinic. Ionising radiation of aqueous polymer solutions is a viable strategy to produce multifunctional nanogels from aqueous solutions of hydrophilic polymers. By proper selection of …
LEMON-DERIVED EXTRACELLULAR VESICLES EXERT ANTI-INFLAMMATORY EFFECTS BY INHIBITING THE ERK/NF-KB PATHWAY
2021
nflammation can be the leading cause of several diseases, including cancer, diabetes, and ulcerative colitis; however, the existing anti-inflammatory drugs cause side effects. For these reasons, it is necessary to find new supportive therapeutic agents. In recent years, plant-derived extracellular vesicles (PDEVs) are gaining increasing interest in the scientific community as they have been found to possess a variety of biological properties; among those, the anti-inflammatory effects have been described by different groups that evaluated the effects of PDEVs in in vitro and in vivo models. We successfully isolated and characterized extracellular vesicles from Citrus limon juice (LEVs) and …