0000000000615723

AUTHOR

David Rubin

showing 2 related works from this author

Measurement of the anomalous precession frequency of the muon in the Fermilab Muon g−2 Experiment

2021

The Muon g-2 Experiment at Fermi National Accelerator Laboratory (FNAL) has measured the muon anomalous precession frequency $\omega_a$ to an uncertainty of 434 parts per billion (ppb), statistical, and 56 ppb, systematic, with data collected in four storage ring configurations during its first physics run in 2018. When combined with a precision measurement of the magnetic field of the experiment's muon storage ring, the precession frequency measurement determines a muon magnetic anomaly of $a_{\mu}({\rm FNAL}) = 116\,592\,040(54) \times 10^{-11}$ (0.46 ppm). This article describes the multiple techniques employed in the reconstruction, analysis and fitting of the data to measure the preces…

Physics::Instrumentation and DetectorsMeasure (physics)FOS: Physical sciences7. Clean energy01 natural sciencesOmegaHigh Energy Physics - ExperimentNuclear physicsHigh Energy Physics - Experiment; High Energy Physics - Experiment; Nuclear ExperimentHigh Energy Physics - Experiment (hep-ex)muon0103 physical sciencesFermilabNuclear Experiment (nucl-ex)010306 general physicsNuclear ExperimentLarmor precessionPhysicsMuon010308 nuclear & particles physicsSettore FIS/01 - Fisica Sperimentaleanomalous magnetic moment3. Good healthMagnetic fieldPhysics::Accelerator PhysicsHigh Energy Physics::ExperimentStorage ringFermi Gamma-ray Space TelescopePhysical Review
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Mepolizumab for eosinophilic chronic obstructive pulmonary disease

2017

BACKGROUNDPatients with chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed against interleukin-5.METHODSWe performed two phase 3, randomized, placebo-controlled, double-blind, parallel-group trials comparing mepolizumab (100 mg in METREX, 100 or 300 mg in METREO) with placebo, given as a subcutaneous injection every 4 weeks for 52 weeks in patients with COPD who had a history of moderate or severe exacerbations while taking inhaled glucocorticoid-based triple maintenance therapy. In METREX, unselected patients in the modified intention-to-treat population with an eosinophilic phenotype were …

medicine.medical_specialtyPARALLEL-GROUPPopulationPlacebo-controlled studyPNEUMONIA RISKPlaceboPLACEBO-CONTROLLED TRIALGastroenterology03 medical and health sciencesDOUBLE-BLIND0302 clinical medicineMaintenance therapyInternal medicineEosinophilicmedicineINHALED FLUTICASONE FUROATE030212 general & internal medicineeducationCOPDeducation.field_of_studyIntention-to-treat analysisCOPD ASSESSMENT TESTSPUTUM EOSINOPHILIAbusiness.industryGeneral MedicineRANDOMIZED CONTROLLED-TRIALBLOOD EOSINOPHILSmedicine.diseaseSECONDARY ANALYSIS030228 respiratory systemImmunologybusinessMepolizumabmedicine.drug
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