0000000000616796
AUTHOR
D Schillaci
New antimicrobial peptides from Tirmania pinoyi and Terfezia boudieri in the struggle against antibiotic resistance
Antibiotic resistance of common pathogenic microorganisms is a topic of great concern that has finally received media attention and entered into the political agenda of world leaders. Drug-resistant bacteria are cause of thousands of deaths worldwide, then there is an urgent need for new antimicrobials, otherwise we risk losing the ability to control effectively the infectious diseases. Such emergence can be faced looking also at not usual source of antimicrobial agents, for example medicinal mushrooms. With the objective to tackle Gram-positive and Gram-negative pathogens, we focused on two edible desert truffles mushrooms Tirmania pinoyi and Terfezia boudieri as origin of new antimicrobia…
ANTIMICROBIAL AND ANTISTAPHYLOCOCCAL BIOFILM ACTIVITY FROM THE SEA URCHIN PARACENTROTUS LIVIDUS
Aims: Staphylococcal biofilm-associated infections are resistant to conventional antibiotics. Consequently, new agents are needed to treat them. With this aim, we focused on the effector cells (coelomocytes) of the sea urchin Paracentrotus lividus immune system. Methods and Results: We tested the activity of the 5-kDa peptide fraction of the cytosol from coelomocytes (5-CC) against a group of Gram-positive, Gram-negative bacteria and fungi. We determined minimal inhibitory concentrations (MICs) ranging from 253.7 to 15.8 mg ml(-1). We observed an inhibitory activity and antibiofilm properties of 5-CC against staphylococcal biofilms of reference strains Staphylococcus epidermidis DSM 3269 an…
A white Maitake (Grifola frondosa): nutritional value and antibacterial preliminary activity test
Grifola frondosa (Dicks.) Gray (Meripilaceae) is a big size, perennial, infrequent lignicolous basidiomycetes, traditionally known as Maitake. Brown or grayish overlapped caps, with a wavy margin, characterize the sporophore. In the wild, it is usually found at the base of living oak trees but it is also cultivated. G. frondosa is mainly distributed in Japan, Asia, Eastern America, and Europe. In Italy, is infrequent but widely distributed in all regions. Field investigation carried out in autumn 2016 in Sicily (southern Italy) permitted to observe an unusual white G. frondosa growing at the base of a living tree of Quercus pubescens Willd. s.l. Once harvested, the mushroom sample was clean…